Lippman M E, Yarbro G K, Leventhal B G
Cancer Res. 1978 Nov;38(11 Pt 2):4251-6.
Glucorticoid receptors were studied in various populations of normal human peripheral blood lymphocytes and leukemic lymphoblasts. Normal lymphocytes contain low levels of glucocorticoid receptor (approximately 2,500 sites/cell) which are identical in T- and non-T-fractions. Phytohemagglutinin treatment increases levels about 3-fold. Leukemic lymphoblasts contain larger numbers of receptor sites. Presence of receptor is correlated with in vitro sensitivitiy to glucocorticoids and in vivo response to therapy. Quantity of receptor is also correlated with complete remission duration independently of leukemic cell type (T or null), initial WBC, or age of patient. Quantitative determination of glucocorticoid receptor levels in acute lymphoblastic leukemia may be of value both as an independent prognostic variable and in suggesting which patients should receive glucocorticoid therapy.
对正常人类外周血淋巴细胞和白血病淋巴母细胞的不同群体中的糖皮质激素受体进行了研究。正常淋巴细胞含有低水平的糖皮质激素受体（约2500个位点/细胞），在T细胞和非T细胞组分中相同。植物血凝素处理可使水平增加约3倍。白血病淋巴母细胞含有更多数量的受体位点。受体的存在与体外对糖皮质激素的敏感性和体内对治疗的反应相关。受体数量也与完全缓解持续时间相关，与白血病细胞类型（T或无）、初始白细胞计数或患者年龄无关。急性淋巴细胞白血病中糖皮质激素受体水平的定量测定作为一个独立的预后变量以及提示哪些患者应接受糖皮质激素治疗可能都有价值。
