在认知功能正常的患者中，通过 [11C]-Pittsburgh 化合物 B PET 计算机断层扫描成像，阻塞性睡眠呼吸暂停综合征的严重程度不能预测脑淀粉样蛋白的积累。
The severity of obstructive sleep apnea syndrome cannot predict the accumulation of brain amyloid by imaging with [11C]-Pittsburgh compound B PET computed tomography in patients with a normal cognitive function.
机构信息
Sleep Apnea Center, Kyushu University Hospital, Fukuoka, Japan.
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
出版信息
Ann Nucl Med. 2019 Jul;33(7):541-544. doi: 10.1007/s12149-019-01349-6. Epub 2019 Mar 18.
OBJECTIVE
Disturbed sleep due to obstructive sleep apnea syndrome (OSAS) might accelerate amyloidβ (Aβ) deposition, which can be a crucial factor in Alzheimer's disease. We studied Aβ deposition in untreated OSAS patients with normal cognition.
METHOD
We performed polysomnography (PSG) and Aβ imaging with [C]-Pittsburgh compound B PET computed tomography (C-PiB PET CT) in 14 untreated OSAS patients (apnea-hypopnea index: 43.8 ± 26.3/h).
RESULTS
The abnormal accumulation of enhanced C-PiB PET was observed only one patient with severe, but not the most severe.
CONCLUSIONS
The OSAS severity alone may not predict Aβ deposition in OSAS patients with normal cognition.
目的
阻塞性睡眠呼吸暂停综合征（OSAS）引起的睡眠障碍可能会加速淀粉样蛋白β（Aβ）沉积，这可能是阿尔茨海默病的一个关键因素。我们研究了认知功能正常的未经治疗的 OSAS 患者的 Aβ沉积情况。
方法
我们对 14 名未经治疗的 OSAS 患者（呼吸暂停-低通气指数：43.8±26.3/小时）进行了多导睡眠图（PSG）和[C]-匹兹堡化合物 B PET 计算机断层扫描（C-PiB PET CT）的 Aβ成像。
结果
仅在一名严重但并非最严重的患者中观察到增强的 C-PiB PET 的异常积聚。
结论
OSAS 严重程度本身可能无法预测认知功能正常的 OSAS 患者的 Aβ 沉积。
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