Tulassay T, Miltényi M, Dobos M
Acta Paediatr Scand. 1986 May;75(3):415-9. doi: 10.1111/j.1651-2227.1986.tb10223.x.
Renal tubular function tests were performed in 45 children suffering from upper and lower urinary tract infections. Determinations were made of the urinary carbon dioxide tension in maximally alkaline urine as an index of distal tubular H+-ion secretion, of urinary protein excretion, and of urinary sodium and phosphate handling. Urinary PCO2 was low (2.7 +/- 13.9 mmHg) in acute pyelonephritis compared to values in healthy children (52 +/- 32 mmHg) or those with cystitis (48 +/- 34 mmHg). At the onset of pyelonephritis an elevated fractional excretion of sodium (1.38 +/- 0.38 vs. 0.50 +/- 0.20%) and decreased phosphate reabsorption (69.2 +/- 7.1 vs. 90.4 +/- 4.9%) were also observed. Significantly elevated urinary low molecular weight protein excretion was also found in pyelonephritis. These data indicate the existence of proximal and distal tubular dysfunction at the onset of acute bacterial pyelonephritis.
对45名患有上、下尿路感染的儿童进行了肾小管功能测试。测定了最大碱性尿液中的尿二氧化碳分压，作为远端肾小管H⁺离子分泌的指标，还测定了尿蛋白排泄以及尿钠和磷酸盐处理情况。与健康儿童（52±32 mmHg）或膀胱炎患儿（48±34 mmHg）的值相比，急性肾盂肾炎患者的尿PCO₂较低（2.7±13.9 mmHg）。在肾盂肾炎发作时，还观察到钠分数排泄升高（1.38±0.38对0.50±0.20%）和磷酸盐重吸收减少（69.2±7.1对90.4±4.9%）。在肾盂肾炎患者中还发现尿低分子量蛋白排泄显著升高。这些数据表明，急性细菌性肾盂肾炎发作时存在近端和远端肾小管功能障碍。
