The State Key Laboratory of Bioreactor Engineering and Key Laboratory for Ultrafine Materials of Ministry of Education, Key Laboratory for Ultrafine Materials of Ministry of Education, Engineering Research Centre for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China.
Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, China.
Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:1407-1414. doi: 10.1016/j.msec.2019.02.083. Epub 2019 Feb 21.
The multidrug resistance of tumor cells has been creating a high requirement on development of nanocarriers for administration of different drugs, among which their drug loading capacity and controllable release properties are the key factors to overcome tumor drug resistance. This study aims to use a kind of bioactive 2D nanoplatelets (25 nm in diameter and 0.92 nm in thickness) to load different anticancer drugs (doxorubicin and methotrexate) via a step-by-step assembly, where variation of each drug amount can be used for adjustment of the sizes of the resulting nanocomplexes. The dual-drug loaded nanosystems allow for a sequential release of the loaded drugs. Furthermore, drug release rate can be accelerated under both acidic pathological triggers of tumors and/or by heating treatment, resulting in a synergistic anticancer bioactivity. The drug-mediated formation of nanocarriers may enlighten a design of novel nanoplatform for co-delivery of therapeutic agents, beyond anticancer drugs, in a combinative way for drug delivery applications.
肿瘤细胞的多药耐药性对不同药物给药的纳米载体的发展提出了很高的要求，其中载药能力和可控释放性能是克服肿瘤耐药性的关键因素。本研究旨在使用一种生物活性二维纳米片（直径 25nm，厚度 0.92nm），通过逐步组装来装载不同的抗癌药物（阿霉素和甲氨蝶呤），其中每种药物的用量变化可用于调整所得纳米复合物的大小。双载药纳米系统允许加载药物的顺序释放。此外，在肿瘤酸性病理触发和/或加热处理下，药物释放速率可以加快，从而产生协同抗癌生物活性。药物介导的纳米载体的形成可能为新型纳米平台的设计提供启示，用于以联合方式递送达疗剂，超越抗癌药物，用于药物递送应用。
