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HOXB7 过表达对人脂肪间充质祖细胞的影响。

Impact of HOXB7 overexpression on human adipose-derived mesenchymal progenitors.

机构信息

Division of Oncology, Department of Medical and Surgical Sciences for Children and Adults, University-Hospital of Modena and Reggio Emilia, Via del Pozzo, 71, 41100, Modena, Italy.

Rigenerand srl, Modena, Medolla, Italy.

出版信息

Stem Cell Res Ther. 2019 Mar 19;10(1):101. doi: 10.1186/s13287-019-1200-6.

DOI:10.1186/s13287-019-1200-6
PMID:30890185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6423808/
Abstract

BACKGROUND

The ex vivo expansion potential of mesenchymal stromal/stem cells (MSC) together with their differentiation and secretion properties makes these cells an attractive tool for transplantation and tissue engineering. Although the use of MSC is currently being tested in a growing number of clinical trials, it is still desirable to identify molecular markers that may help improve their performance both in vitro and after transplantation.

METHODS

Recently, HOXB7 was identified as a master player driving the proliferation and differentiation of bone marrow mesenchymal progenitors. In this study, we investigated the effect of HOXB7 overexpression on the ex vivo features of adipose mesenchymal progenitors (AD-MSC).

RESULTS

HOXB7 increased AD-MSC proliferation potential, reduced senescence, and improved chondrogenesis together with a significant increase of basic fibroblast growth factor (bFGF) secretion.

CONCLUSION

While further investigations and in vivo models shall be applied for better understanding, these data suggest that modulation of HOXB7 may be a strategy for innovative tissue regeneration applications.

摘要

背景

间充质基质/干细胞（MSC）的体外扩增潜力及其分化和分泌特性使这些细胞成为移植和组织工程的有吸引力的工具。尽管 MSC 的使用目前正在越来越多的临床试验中进行测试，但仍需要确定分子标志物，以帮助提高其在体外和移植后的性能。

方法

最近，HOXB7 被鉴定为驱动骨髓间充质祖细胞增殖和分化的主要调控因子。在这项研究中，我们研究了 HOXB7 过表达对脂肪间充质祖细胞（AD-MSC）的体外特征的影响。

结果

HOXB7 增加了 AD-MSC 的增殖潜力，减少了衰老，并改善了软骨生成，同时显著增加了碱性成纤维细胞生长因子（bFGF）的分泌。

结论

虽然需要进一步的研究和体内模型来更好地理解，但这些数据表明，HOXB7 的调节可能是一种创新的组织再生应用策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24d/6423808/358f7ac7e61a/13287_2019_1200_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24d/6423808/9e6eca915b41/13287_2019_1200_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24d/6423808/fa1aa820cc1d/13287_2019_1200_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24d/6423808/41c2a151f2b5/13287_2019_1200_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24d/6423808/7de13e88079c/13287_2019_1200_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24d/6423808/358f7ac7e61a/13287_2019_1200_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24d/6423808/9e6eca915b41/13287_2019_1200_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24d/6423808/fa1aa820cc1d/13287_2019_1200_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24d/6423808/41c2a151f2b5/13287_2019_1200_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24d/6423808/7de13e88079c/13287_2019_1200_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f24d/6423808/358f7ac7e61a/13287_2019_1200_Fig5_HTML.jpg

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