Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass.
Am J Med. 2019 Jul;132(7):802-807. doi: 10.1016/j.amjmed.2019.03.001. Epub 2019 Mar 16.
Parkinson's disease is a progressive neurodegenerative disease characterized by tremor and bradykinesia and is a common neurologic ailment. Male sex and advancing age are independent risk factors and, as the population ages, is taking an increasing toll on productivity and medical resources. There are a number of other extrapyramidal conditions that can make the diagnosis challenging. Unlike other neurodegenerative diseases, idiopathic Parkinson's disease has effective treatments that mitigate symptoms. Medications can improve day-to-day function and, in cases where medication does not give a sustained benefit or has significant side effects, treatments like deep brain stimulation result in improved quality of life.
帕金森病是一种进行性神经退行性疾病,其特征是震颤和运动迟缓,是一种常见的神经疾病。男性和年龄增长是独立的危险因素,随着人口老龄化,它对生产力和医疗资源造成的损失越来越大。还有许多其他的锥体外系疾病会使诊断变得具有挑战性。与其他神经退行性疾病不同,特发性帕金森病有有效的治疗方法可以减轻症状。药物可以改善日常生活功能,在药物不能持续获益或有明显副作用的情况下,深部脑刺激等治疗方法可以提高生活质量。