Lauroua P, Barbier F, Dieu P, Dumora D, Moulinier J
Ann Fr Anesth Reanim. 1986;5(2):154-6. doi: 10.1016/s0750-7658(86)80097-1.
A forty-one year old severe haemophiliac A (factor VIII less than 1%) complicated by an antifactor VIII inhibitor was operated on for a bilateral arthroplasty of the knees. Substitutive treatment was started by giving anti-haemophilic A cryoprecipitate at a dose of 40 IU . kg-1. The anamnestic response occurred at day 6. Consumption of the inhibitor begun with the injection of 50,000 IU of concentrated factor VIII. This method proved to be insufficient for mastering the haemorrhagic syndrome, because the antibody titre quickly reached 10 IU Oxford. Treatment was continued with Autoplex (100 IU . kg-1), during three weeks, without any clinical or biological complications. It is suggested that Autoplex be used as the substitutive treatment in cases of major surgery in severe haemophilia complicated by a factor VIII inhibitor.
一名41岁的重度甲型血友病患者（因子VIII低于1%）合并抗因子VIII抑制剂，接受了双膝双侧关节置换手术。替代治疗从给予剂量为40 IU·kg-1的甲型血友病冷沉淀开始。回忆反应在第6天出现。抑制剂消耗始于注射50,000 IU浓缩因子VIII。该方法被证明不足以控制出血综合征，因为抗体滴度迅速达到10 IU牛津单位。继续使用重组凝血因子复合物（100 IU·kg-1）进行治疗，持续三周，未出现任何临床或生物学并发症。建议在重度血友病合并因子VIII抑制剂的大手术病例中，将重组凝血因子复合物用作替代治疗。
