Moeller R, Kozak-Reiss G, Gascard J P, Laxenaire M C
Ann Fr Anesth Reanim. 1986;5(2):177-81. doi: 10.1016/s0750-7658(86)80105-8.
The results are reported of the contracture test obtained by using the calcium ionophore A 23187 (Calcimycin) in two patients, the son (A) and the mother (B). The past history of patient A revealed the occurrence of an impending malignant hyperthermia crisis during induction of anaesthesia in 1975. The A 23187 contracture test confirmed the presence of the malignant hyperthermia trait in patient A, whose muscle biopsy had been submitted to the caffeine contracture test, according to Ellis' technique, and found to be positive in the presence of 1 mmol of caffeine in the tissue bath; the contracture test could not be completed with a halothane contracture test, due to the impaired viability of the muscle fibres obtained. On the reverse, the mother (patient B) was found to be negative to the tests applied: the caffeine contracture test, the halothane contracture test and the contracture test performed with the calcium ionophore A 23187. It is suggested the A 23187 contracture test be added to the contracture tests as defined by the European Malignant Hyperpyrexia Group. This test could be of great help in identifying the percentage of relatives of MHS ("malignant hyperthermia susceptible") patients found to be MHE ("malignant hyperthermia equivocal").
报告了在两名患者（儿子（A）和母亲（B））身上使用钙离子载体A 23187（钙霉素）进行挛缩试验的结果。患者A的既往史显示，1975年在麻醉诱导期间发生过即将出现的恶性高热危机。A 23187挛缩试验证实患者A存在恶性高热特征，其肌肉活检已按照埃利斯技术进行咖啡因挛缩试验，发现在组织浴中有1 mmol咖啡因时呈阳性；由于获得的肌纤维活力受损，无法用氟烷挛缩试验完成挛缩试验。相反，母亲（患者B）被发现对所应用的试验均为阴性：咖啡因挛缩试验、氟烷挛缩试验以及用钙离子载体A 23187进行的挛缩试验。建议将A 23187挛缩试验添加到欧洲恶性高热小组定义的挛缩试验中。该试验对于确定被发现为MHE（“恶性高热可疑”）的MHS（“恶性高热易感”）患者亲属的比例可能有很大帮助。
