Isaacs H, Badenhorst M
Muscular Dystrophy Research Foundation, South Africa Laboratory, Department of Physiology, Witwatersrand University Medical School, Parktown.
Anesthesiology. 1993 Jul;79(1):5-9. doi: 10.1097/00000542-199307000-00003.
During the period 1985-1991, 350 muscle contracture studies have been performed in the authors' laboratory, and during this period, they became aware of an occasional false-negative result. The findings pertaining to the four cases so classified are presented in detail.
In 1985 the protocol for the muscle strip caffeine halothane testing procedure adopted was that of the European Malignant Hyperthermia Society.
Thirty-six percent of the cases tested susceptible for malignant hyperthermia, 15% tested equivocal in that they responded either to halothane or to caffeine singularly, and 49% gave a normal response. In this latter group, the authors believe they identified four false-negative results.
This study documents the rarity of false-negative results and substantiates the reliability of caffeine halothane testing as a biologic test in diagnosing the presence of a potentially serious problem.
在1985年至1991年期间，作者所在实验室进行了350项肌肉挛缩研究，在此期间，他们意识到偶尔会出现假阴性结果。现将与这四例如此分类的病例相关的研究结果详细呈现。
1985年采用的肌肉条咖啡因氟烷测试程序的方案是欧洲恶性高热协会的方案。
36%的测试病例对恶性高热易感，15%的测试结果不明确，因为它们仅对氟烷或咖啡因有反应，49%的病例反应正常。在后者这一组中，作者认为他们识别出了四个假阴性结果。
本研究记录了假阴性结果的罕见性，并证实了咖啡因氟烷测试作为诊断潜在严重问题的生物学测试的可靠性。
