阿尔茨海默病中的细胞黏附分子
Cell adhesion molecules in Alzheimer's disease.
作者信息
Wennström Malin, Nielsen Henrietta M
机构信息
Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden,
出版信息
Degener Neurol Neuromuscul Dis. 2012 Jul 4;2:65-77. doi: 10.2147/DNND.S19829. eCollection 2012.
Abstract
Cell adhesion molecules (CAMs) mediate interactions between cells and their surroundings that are vital to processes controlling for cell survival, activation, migration, and plasticity. However, increasing evidence suggests that CAMs also mediate mechanisms involved in several neurological diseases. This article reviews the current knowledge on the role of CAMs in amyloid-β (Aβ) metabolism, cell plasticity, neuroinflammation, and vascular changes, all of which are considered central to the pathogenesis and progression of Alzheimer's disease (AD). This paper also outlines the possible roles of CAMs in current and novel AD treatment strategies.
摘要
细胞黏附分子（CAMs）介导细胞与其周围环境之间的相互作用，这些相互作用对于控制细胞存活、激活、迁移和可塑性的过程至关重要。然而，越来越多的证据表明，CAMs也介导了几种神经系统疾病所涉及的机制。本文综述了关于CAMs在淀粉样β蛋白（Aβ）代谢、细胞可塑性、神经炎症和血管变化中作用的现有知识，所有这些都被认为是阿尔茨海默病（AD）发病机制和进展的核心。本文还概述了CAMs在当前和新型AD治疗策略中的可能作用。
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