Grochowski Cezary, Blicharska Eliza, Krukow Paweł, Jonak Kamil, Maciejewski Marcin, Szczepanek Dariusz, Jonak Katarzyna, Flieger Jolanta, Maciejewski Ryszard
Department of Anatomy, Medical University of Lublin, Lublin, Poland.
Department of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Lublin, Poland.
Front Chem. 2019 Mar 5;7:115. doi: 10.3389/fchem.2019.00115. eCollection 2019.
Trace elements play a crucial role in many biochemical processes, mainly as components of vitamins and enzymes. Although small amounts of metal ions have protective properties, excess metal levels result in oxidative injury, which is why metal ion homeostasis is crucial for the proper functioning of the brain. The changes of their level in the brain have been proven to be a risk factor for Alzheimer's, Parkinson's, and Huntington's diseases, as well as amyotrophic lateral sclerosis. Therefore, it is currently an important application of various analytical methods. This review covers the most important of them: inductively coupled ground mass spectrometry (ICP-MS), flame-induced atomic absorption spectrometry (FAAS), electrothermal atomic absorption spectrometry (GFAAS), optical emission spectrometry with excitation in inductively coupled plasma (ICP-OES), X-ray fluorescence spectrometry (XRF), and neutron activation analysis (NAA). Additionally, we present a summary of concentration values found by different research groups.
微量元素在许多生物化学过程中起着至关重要的作用，主要作为维生素和酶的组成部分。尽管少量金属离子具有保护特性，但过量的金属水平会导致氧化损伤，这就是为什么金属离子稳态对大脑的正常运作至关重要。已证明它们在大脑中的水平变化是阿尔茨海默病、帕金森病、亨廷顿病以及肌萎缩侧索硬化症的危险因素。因此，目前各种分析方法的应用很重要。本综述涵盖了其中最重要的方法：电感耦合等离子体质谱法（ICP-MS）、火焰原子吸收光谱法（FAAS）、石墨炉原子吸收光谱法（GFAAS）、电感耦合等离子体发射光谱法（ICP-OES）、X射线荧光光谱法（XRF）和中子活化分析法（NAA）。此外，我们还总结了不同研究小组发现的浓度值。
