一种用于活性硫物种、次磺酸硫的可逆荧光探针的开发及其生物学应用。
Development of a reversible fluorescent probe for reactive sulfur species, sulfane sulfur, and its biological application.
作者信息
Takano Yoko, Hanaoka Kenjiro, Shimamoto Kazuhito, Miyamoto Ryo, Komatsu Toru, Ueno Tasuku, Terai Takuya, Kimura Hideo, Nagano Tetsuo, Urano Yasuteru
机构信息
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan.
出版信息
Chem Commun (Camb). 2017 Jan 17;53(6):1064-1067. doi: 10.1039/c6cc08372b.
We report a reversible off/on fluorescent probe for monitoring concentration changes of sulfane sulfur by utilizing the unique ability of sulfane sulfur to bind reversibly to other sulfur atoms and the intramolecular spirocyclization reaction of xanthene dyes. It reversibly visualized sulfane sulfur in living A549 cells and primary-cultured hippocampal astrocytes.
我们报道了一种可逆的开/关荧光探针，该探针利用硫烷硫与其他硫原子可逆结合的独特能力以及呫吨染料的分子内螺环化反应来监测硫烷硫的浓度变化。它在活的A549细胞和原代培养的海马星形胶质细胞中可逆地可视化硫烷硫。
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