Narisawa T, Takahashi M, Masuda T, Nagasawa O, Ogata N, Niwa M
Gan To Kagaku Ryoho. 1986 Apr;13(4 Pt 2):1329-35.
Carcinomas produce elevated quantities of prostaglandins (PGs), particularly the E series, which can play an important role in the suppression of the cellular immune reaction in tumor-bearing individuals. These findings have raised the possibility that PG synthetase inhibitor can restore the immune activity against tumors. The anti-tumor activity of indomethacin, a potent PG synthetase inhibitor, was investigated in mice implanted with colon carcinoma 38, colon carcinoma 26 and Lewis lung carcinoma in a series of model studies for cancer treatment in man. Treatment with indomethacin substantially reduced the levels of PGs, particularly PGE2 in tumor tissue, inhibited the tumor growth, particularly the early stage of cell proliferation, prolonged the survival time, eliminated tumors in the abdominal cavity, and inhibited metastatic tumor recurrence after surgery. Also, the treatment reduced the growth of human gastric and colon carcinomas transplanted into nude mice. Thus, indomethacin might also be effective against human carcinomas. It is postulated that PG synthetase inhibitor may prove to be a good therapeutic tool effective against human cancer when used in combination with chemotherapeutic and other immunotherapeutic drugs as well as with low-dose radiation therapy.
癌组织会产生大量的前列腺素（PGs），尤其是E系列，它们在抑制荷瘤个体的细胞免疫反应中可能起重要作用。这些发现增加了PG合成酶抑制剂能够恢复抗肿瘤免疫活性的可能性。在一系列针对人类癌症治疗的模型研究中，研究了强效PG合成酶抑制剂吲哚美辛对植入结肠癌38、结肠癌26和Lewis肺癌的小鼠的抗肿瘤活性。用吲哚美辛治疗可显著降低肿瘤组织中PGs的水平，尤其是PGE2，抑制肿瘤生长，特别是细胞增殖的早期阶段，延长生存时间，消除腹腔内肿瘤，并抑制术后转移性肿瘤复发。此外，该治疗还抑制了移植到裸鼠体内的人胃癌和结肠癌的生长。因此，吲哚美辛可能对人类癌症也有效。据推测，当PG合成酶抑制剂与化疗药物、其他免疫治疗药物以及低剂量放射治疗联合使用时，可能被证明是一种有效的抗人类癌症的治疗工具。
