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Do eosinophils contribute to oxidative stress in mild asthma?

作者信息

de Groot Linsey E S, Sabogal Piñeros Yanaika S, Bal Suzanne M, van de Pol Marianne A, Hamann Jörg, Sterk Peter J, Kulik Wim, Lutter René

机构信息

Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

出版信息

Clin Exp Allergy. 2019 Jun;49(6):929-931. doi: 10.1111/cea.13389. Epub 2019 Apr 9.

DOI:10.1111/cea.13389

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6850153/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/130a/6850153/c4e758f94794/CEA-49-929-g001.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/130a/6850153/c4e758f94794/CEA-49-929-g001.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/130a/6850153/c4e758f94794/CEA-49-929-g001.jpg

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本文引用的文献

[1]

Anti-IL-5 in Mild Asthma Alters Rhinovirus-induced Macrophage, B-Cell, and Neutrophil Responses (MATERIAL). A Placebo-controlled, Double-Blind Study.

Am J Respir Crit Care Med. 2019-2-15

[2]

Functional activity of peripheral blood eosinophils in allergen-induced late-phase airway inflammation in asthma patients.

J Inflamm (Lond). 2015-3-29

[3]

Mepolizumab for prednisone-dependent asthma with sputum eosinophilia.

N Engl J Med. 2009-3-5

[4]

Mepolizumab and exacerbations of refractory eosinophilic asthma.

N Engl J Med. 2009-3-5

[5]

Increased oxidative stress and altered levels of antioxidants in asthma.

J Allergy Clin Immunol. 2003-1

[6]

Eosinophils are a major source of nitric oxide-derived oxidants in severe asthma: characterization of pathways available to eosinophils for generating reactive nitrogen species.

J Immunol. 2001-5-1

[7]

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response.

Lancet. 2000

[8]

Eosinophils generate brominating oxidants in allergen-induced asthma.

J Clin Invest. 2000-5

[9]

Activation of human eosinophils in vitro by respiratory syncytial virus.

Pediatr Res. 1992-8

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