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[2017年江苏省疟疾诊断参比实验室结果分析]

[Results analysis of Jiangsu Provincial Malaria Diagnostic Reference Laboratory in 2017].

作者信息

Sui Xu, Ya-Ping Gu, Yuan-Yuan Cao, Wei-Ming Wang, Jian-Xia Tang, Ju-Lin Li, Mei-Hua Zhang, Hua-Yun Zhou, Guo-Ding Zhu, Jun Cao

机构信息

Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China.

出版信息

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2018 Nov 27;30(6):630-634. doi: 10.16250/j.32.1374.2018267.

Abstract

OBJECTIVE

To analyze the results of samples testing of Jiangsu Provincial Malaria Diagnostic Reference Laboratory in 2017, so as to provide the evidence for improving the malaria diagnostic performance in this province.

METHODS

The samples of reported malaria cases in Jiangsu were collected by the provincial reference laboratory (PRL) in 2017. The microscopy and nucleic acid test were performed to confirm the infection of species of each case, while antigen tests (rapid diagnostic test, RDT) were performed as well. The detection results were analyzed among different areas and different species.

RESULTS

Totally 242 malaria cases were reported and the samples were collected by PRL in 2017. A total of 239 cases were confirmed infections, including 163 cases of infection, 21 cases of infection, 11 cases of infection, 43 cases of infection, and 1 case of and mixed-infection. The diagnostic coincidence rates of reported malaria case in 13 prefectures with districts were all > 80%, and the total coincidence rate was 88.8%. The species diagnostic coincidence rates of , , , and were 98.8%, 57.1%, 63.6%, and 81.4% respectively, and the detection rates by RDT to those four species infections were 95.7%, 85.0%, 63.6% and 79.1% respectively.

CONCLUSIONS

In 2017, the malaria diagnostic quality of medical technicians is generally high in Jiangsu Province. However, the diagnostic capacity is slightly different among different regions, and the ability to identify non- parasites remains to be improved. RDT is not ideal for the detection of non- infection. In the current stage of malaria elimination, the malaria diagnostic capacity of technicians in all the sectors should be strengthened and maintained.

摘要

目的

分析江苏省疟疾诊断参比实验室2017年样本检测结果,为提高该省疟疾诊断水平提供依据。

方法

江苏省疟疾诊断参比实验室收集2017年全省报告疟疾病例的样本。采用显微镜检查和核酸检测确定各病例的疟原虫感染种类,同时进行疟原虫抗原检测(快速诊断检测,RDT)。对不同地区和不同种类的检测结果进行分析。

结果

2017年全省共报告疟疾病例242例,参比实验室收集了相应样本。共确诊239例感染病例,其中间日疟感染163例,恶性疟感染21例,三日疟感染11例,卵形疟感染43例,间日疟与卵形疟混合感染1例。13个设区市报告疟疾病例的诊断符合率均>80%,总符合率为88.8%。间日疟、恶性疟、三日疟和卵形疟的种类诊断符合率分别为98.8%、57.1%、63.6%和81.4%,RDT对这4种疟原虫感染的检测率分别为95.7%、85.0%、63.6%和79.1%。

结论

2017年江苏省疟疾病例诊断质量总体较高。但不同地区诊断能力略有差异,非间日疟原虫的识别能力仍有待提高。RDT对非间日疟感染的检测效果不理想。在当前疟疾消除阶段,应加强并维持各部门技术人员的疟疾诊断能力。

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