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维生素A补充剂的效果:一项系统评价。

Efect of vitamin A suplementation: a systematic review.

作者信息

Soares Marcela Martins, Silva Mariane Alves, Garcia Pauliana Pimentel Coelho, Silva Luciana Saraiva da, Costa Glauce Dias da, Araújo Raquel Maria Amaral, Cotta Rosângela Minardi Mitre

机构信息

Ciência da Nutrição, Departamento de Nutrição e Saúde, Universidade Federal de Viçosa. Ed. Centro de Ciências Biológicas II Centro Universitário. 36570-000 Viçosa MG Brasil.

Estratégia Saúde da Família Santa Clara - Coelhas/Sol Nascente. Viçosa MG Brasil.

出版信息

Cien Saude Colet. 2019 Mar;24(3):827-838. doi: 10.1590/1413-81232018243.07112017.

Abstract

To evaluate the effect of vitamin A supplementation in postpartum infants and women on serum retinol levels and breast milk. The databases Medline, PubMed, Lilacs and SciELO were consulted. The descriptors used were vitamin A, dietary supplement, child, postpartum period, infant and nutrition programs policies. Search found 7432 articles. After elimination of duplicity and application of eligibility criteria, 8 studies remained. All evaluated the effect of vitamin A supplementation on immediate postpartum, five studies used retinyl palmitate supplementation, one with retinyl palmitate and two did not specify the form of supplementation. Six studies evaluated colostrum and two included supplementation of children. It was found that supplementation in the puerperium increases the concentrations of serum retinol and breast milk, however, this result was in the short term and was relevant when the previous concentrations of the mother were low. When maternal serum concentrations are adequate, the retinol content in milk does not change, with little relevance for children. Further studies should be performed to evaluate the effect of megadoses supplementation on serum concentrations of children.

摘要

评估产后婴儿和妇女补充维生素A对血清视黄醇水平和母乳的影响。查阅了Medline、PubMed、Lilacs和SciELO数据库。使用的描述词为维生素A、膳食补充剂、儿童、产后期、婴儿和营养项目政策。检索到7432篇文章。在消除重复并应用纳入标准后,剩下8项研究。所有研究均评估了产后立即补充维生素A的效果,5项研究使用棕榈酸视黄酯补充剂,1项使用棕榈酸视黄酯且2项未指明补充形式。6项研究评估了初乳,2项纳入了儿童补充情况。结果发现,产褥期补充维生素A可提高血清视黄醇和母乳的浓度,然而,这一结果是短期的,且当母亲之前的浓度较低时才有意义。当母亲血清浓度充足时,母乳中的视黄醇含量不变,对儿童影响不大。应开展进一步研究以评估大剂量补充对儿童血清浓度的影响。

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