Division of Periodontics, Department of Prosthodontics and Periodontics, School of Dentistry, State University of Campinas - UNICAMP, Piracicaba, São Paulo, Brazil.
Dental Research Division, School of Dentistry, Paulista University, São Paulo, São Paulo, Brazil.
Periodontol 2000. 2019 Feb;79(1):22-55. doi: 10.1111/prd.12246.
The recognition of a periodontal therapy as a regenerative procedure requires the demonstration of new cementum, periodontal ligament, and bone coronal to the base of the defect. A diversity of regenerative strategies has been evaluated, including root surface conditioning, bone grafts and bone substitute materials, guided tissue regeneration, enamel matrix proteins, growth/differentiation factors, combined therapies and, more recently, tissue-engineering approaches. The aim of this chapter of Periodontology 2000 is to review the research carried out in Latin America in the field of periodontal regeneration, focusing mainly on studies using preclinical models (animal models) and randomized controlled clinical trials. This review may help clinicians and researchers to evaluate the current status of the therapies available and to discuss the challenges that must be faced in order to achieve predictable periodontal regeneration in clinical practice.
牙周治疗被认为是一种再生性治疗方法，需要在缺损的基底上方显示出新的牙骨质、牙周韧带和牙槽骨。已经评估了多种再生策略，包括根面处理、骨移植和骨替代材料、引导组织再生、釉基质蛋白、生长/分化因子、联合治疗，以及最近的组织工程方法。《牙周病学 2000》这一章的目的是回顾拉丁美洲在牙周再生领域开展的研究，主要侧重于使用临床前模型（动物模型）和随机对照临床试验的研究。这一综述可以帮助临床医生和研究人员评估现有治疗方法的现状，并讨论在临床实践中实现可预测的牙周再生所必须面对的挑战。
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