Zhao Fengxiao, Zhang Zhijun, Guo Weihua
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Front Bioeng Biotechnol. 2024 Feb 22;12:1356580. doi: 10.3389/fbioe.2024.1356580. eCollection 2024.
Tooth loss or damage poses great threaten to oral and general health. While contemporary clinical treatments have enabled tooth restoration to a certain extent, achieving functional tooth regeneration remains a challenging task due to the intricate and hierarchically organized architecture of teeth. The past few decades have seen a rapid development of three-dimensional (3D) printing technology, which has provided new breakthroughs in the field of tissue engineering and regenerative dentistry. This review outlined the bioactive materials and stem/progenitor cells used in dental regeneration, summarized recent advancements in the application of 3D printing technology for tooth and tooth-supporting tissue regeneration, including dental pulp, dentin, periodontal ligament, alveolar bone and so on. It also discussed current obstacles and potential future directions, aiming to inspire innovative ideas and encourage further development in regenerative medicine.
牙齿缺失或损坏对口腔和全身健康构成巨大威胁。虽然当代临床治疗已在一定程度上实现了牙齿修复，但由于牙齿复杂且层次分明的组织结构，实现功能性牙齿再生仍是一项具有挑战性的任务。在过去几十年中，三维（3D）打印技术迅速发展，为组织工程和再生牙科领域带来了新的突破。本综述概述了用于牙齿再生的生物活性材料和干/祖细胞，总结了3D打印技术在牙齿及牙齿支持组织再生应用方面的最新进展，包括牙髓、牙本质、牙周韧带、牙槽骨等。还讨论了当前的障碍和未来潜在的发展方向，旨在激发创新思维并促进再生医学的进一步发展。
