正常乳腺组织中 3D MR 指纹成像弛豫测量的可重复性和可再现性。

Repeatability and reproducibility of 3D MR fingerprinting relaxometry measurements in normal breast tissue.

机构信息

Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Department of Radiology, University of North Carolina, Chapel Hill, North Carolina, USA.

出版信息

J Magn Reson Imaging. 2019 Oct;50(4):1133-1143. doi: 10.1002/jmri.26717. Epub 2019 Mar 20.

DOI:10.1002/jmri.26717

PMID:30892807

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6750981/

Abstract

BACKGROUND

The 3D breast magnetic resonance fingerprinting (MRF) technique enables T and T mapping in breast tissues. Combined repeatability and reproducibility studies on breast T and T relaxometry are lacking.

PURPOSE

To assess test-retest and two-visit repeatability and interscanner reproducibility of the 3D breast MRF technique in a single-institution setting.

STUDY TYPE

Prospective.

SUBJECTS

Eighteen women (median age 29 years, range, 22-33 years) underwent Visit 1 scans on scanner 1. Ten of these women underwent test-retest scan repositioning after a 10-minute interval. Thirteen women had Visit 2 scans within 7-15 days in same menstrual cycle. The remaining five women had Visit 2 scans in the same menstrual phase in next menstrual cycle. Five women were also scanned on scanner 2 at both visits for interscanner reproducibility.

FIELD STRENGTH/SEQUENCE: Two 3T MR scanners with the 3D breast MRF technique.

ASSESSMENT

T and T MRF maps of both breasts.

STATISTICAL TESTS

Mean T and T values for normal fibroglandular tissues were quantified at all scans. For variability, between and within-subjects coefficients of variation (bCV and wCV, respectively) were assessed. Repeatability was assessed with Bland-Altman analysis and coefficient of repeatability (CR). Reproducibility was assessed with interscanner coefficient of variation (CoV) and Wilcoxon signed-rank test.

RESULTS

The bCV at test-retest scans was 9-12% for T , 7-17% for T , wCV was <4% for T , and <7% for T . For two visits in same menstrual cycle, bCV was 10-15% for T , 13-17% for T , wCV was <7% for T and <5% for T . For two visits in the same menstrual phase, bCV was 6-14% for T , 15-18% for T , wCV was <7% for T , and <9% for T . For test-retest scans, CR for T and T were 130 msec and 11 msec. For two visit scans, CR was <290 msec for T and 10-14 msec for T . Interscanner CoV was 3.3-3.6% for T and 5.1-6.6% for T , with no differences between interscanner measurements (P = 1.00 for T , P = 0.344 for T ).

DATA CONCLUSION

3D breast MRF measurements are repeatable across scan timings and scanners and may be useful in clinical applications in breast imaging.

LEVEL OF EVIDENCE

2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:1133-1143.

摘要

背景

3D 乳腺磁共振指纹（MRF）技术可在乳腺组织中进行 T1 和 T2 映射。目前缺乏关于乳腺 T1 和 T2 弛豫度的重复性和再现性的综合研究。

目的

在单机构环境中评估 3D 乳腺 MRF 技术的测试-重测和两次访问的重复性以及扫描仪间的可重复性。

研究类型

前瞻性。

受试者

18 名女性（中位年龄 29 岁，范围 22-33 岁）在扫描仪 1 上进行了第一次就诊扫描。其中 10 名女性在 10 分钟的间隔后进行了测试-重测扫描重新定位。13 名女性在相同的月经周期内的 7-15 天内进行了第二次就诊扫描。其余 5 名女性在接下来的月经周期的相同月经阶段进行了第二次就诊扫描。还有 5 名女性在两次就诊时均在扫描仪 2 上进行了扫描仪间的可重复性扫描。

磁场强度/序列：两台 3T 磁共振扫描仪，均配备了 3D 乳腺 MRF 技术。

评估

双侧乳房的 T1 和 T2 MRF 图谱。

统计检验

所有扫描中均对正常纤维腺体组织的平均 T1 和 T2 值进行了量化。为了评估变异性，分别评估了组内和组间变异系数（bCV 和 wCV）。采用 Bland-Altman 分析和可重复性系数（CR）评估重复性。采用扫描仪间变异系数（CoV）和 Wilcoxon 符号秩检验评估再现性。

结果

测试-重测扫描的 bCV 为 T1 9-12%，T2 7-17%，wCV 为 T1 <4%，T2 <7%。在同一月经周期的两次就诊中，T1 的 bCV 为 10-15%，T2 的 bCV 为 13-17%，wCV 为 T1 <7%，T2 <5%。在同一月经阶段的两次就诊中，T1 的 bCV 为 6-14%，T2 的 bCV 为 15-18%，wCV 为 T1 <7%，T2 <9%。对于测试-重测扫描，T1 和 T2 的 CR 分别为 130 毫秒和 11 毫秒。对于两次就诊扫描，T1 的 CR 小于 290 毫秒，T2 的 CR 为 10-14 毫秒。扫描仪间 CoV 为 T1 3.3-3.6%，T2 5.1-6.6%，两次扫描之间无差异（T1 的 P 值=1.00，T2 的 P 值=0.344）。