Visch Marjolein Birgitte M B, Kreike Bas B, Gerritsen Marie-Jeanne Pieternel M J P
Department of Dermatology, Rijnstate Hospital, Arnhem, Netherlands.
Radiotherapy Group, Institute for Radiation Oncology, Arnhem, Netherlands.
J Dermatolog Treat. 2020 May;31(3):290-295. doi: 10.1080/09546634.2019.1592099. Epub 2019 Mar 25.
In the Netherlands, the incidence of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin is increasing dramatically. Radiotherapy is one of the treatment options, especially for the high risk and the irradical excised tumours. Retrospectively, the treatment outcome of all patients with BCC or SCC treated with radiotherapy in the period 2000-2013, were reviewed. Patients were divided into two groups, i.e. patients primarily treated with radiotherapy ( 583) and patients with adjuvant radiation after irradical surgical excision ( 140). With respect to the treatment outcome, after a median follow-up of 3.4 years for the primarily treated BCCs, 6.5% of the tumours recurred (3-year local control rate for stage I: 93.3% and stage II: 94.4%). 12.7% of the primarily treated SCCs recurred after a median follow-up of 2.4 years (3-year local control rate for stage I: 92.0% and stage II: 83.7%). Local recurrence rates for post-operatively irradiated tumours were 3.6% for BCCs and 11.5% for SCCs. The yearly number of patients with BCC or SCC treated with radiotherapy does not reflect the increasing incidence of these tumours. Radiotherapy has potential good treatment outcome in terms of local control and toxicity and seem to be predominantly chosen for tumours located in the head-and-neck area.
在荷兰，皮肤基底细胞癌（BCC）和鳞状细胞癌（SCC）的发病率正在急剧上升。放射治疗是治疗选择之一，尤其是对于高危和切除不彻底的肿瘤。回顾性地分析了2000年至2013年期间所有接受放射治疗的BCC或SCC患者的治疗结果。患者分为两组，即主要接受放射治疗的患者（583例）和手术切除不彻底后接受辅助放疗的患者（140例）。关于治疗结果，主要接受治疗的BCC患者中位随访3.4年，6.5%的肿瘤复发（I期3年局部控制率：93.3%，II期：94.4%）。主要接受治疗的SCC患者中位随访2.4年后，12.7%复发（I期3年局部控制率：92.0%，II期：83.7%）。术后接受放疗的肿瘤，BCC的局部复发率为3.6%，SCC为11.5%。接受放射治疗的BCC或SCC患者的年数量并未反映出这些肿瘤发病率的上升。放射治疗在局部控制和毒性方面有潜在的良好治疗效果，似乎主要用于头颈部区域的肿瘤。
