Thorpe Daniel
School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia.
Curr Opin Support Palliat Care. 2019 Jun;13(2):114-118. doi: 10.1097/SPC.0000000000000423.
Alimentary mucositis is a severe dose limiting side effect of chemotherapy and radiotherapy. Mucin expression and secretion are associated with mucositis. This article aims to review current studies involving mucin and mucositis.
Mucins have been shown to alter mucositis severity and key targets associated with mucositis. First, interventions increasing mucin content has been associated with reduce damage associated with mucositis. Second, mucins have also been shown to protect microbiota from radiation-induced damage. Finally, mucins have also been shown to be involved in lumen epithelial barrier interactions altering signalling for cell proliferation, motility, and the inhibition of apoptosis.
The current studies suggest that mucin expression prior to and during mucositis may be very important in reducing the severity of mucositis and further research into the area is warranted.
消化道黏膜炎是化疗和放疗严重的剂量限制性副作用。黏蛋白的表达和分泌与黏膜炎相关。本文旨在综述目前有关黏蛋白和黏膜炎的研究。
已表明黏蛋白可改变黏膜炎严重程度及与黏膜炎相关的关键靶点。首先，增加黏蛋白含量的干预措施与减少黏膜炎相关损伤有关。其次，黏蛋白还被证明可保护微生物群免受辐射诱导的损伤。最后，黏蛋白还被证明参与管腔上皮屏障相互作用，改变细胞增殖、运动及凋亡抑制的信号传导。
目前的研究表明，黏膜炎发生之前及期间的黏蛋白表达对于减轻黏膜炎严重程度可能非常重要，该领域值得进一步研究。
