[高渗甘露醇溶液对离体蛙心梗死周边区域的影响]

[Effect of a hypertonic mannitol solution on the peri-infarct area of an isolated frog heart].

作者信息

Kopylova G N, Karazeeva E P, Sokolova N A

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1986(5):53-7.

Abstract

The influence of the hypertonic (3%) solution of mannitol on the process of the excitability recovery (in the near necrotic zone) appeared as a result of the necroses tissue effect on the ventricle has been investigated in the experiments on the isolated frog's heart. The analogous perfusion was conducted by Ringer solution in the control experiments. The process of isopotential phase S-T recovery was practically the same at heart perfusion with Ringer solution or with mannitol. Simultaneous registration of ventricular mechanogram showed the pronounced negative inotropic effect of mannitol. It is suggested that the positive effect of mannitol which has been noted under clinic conditions during the treatment of ischemic disease, doesn't connect with the effect of hypertonic solution on the cells excitability of periinfarcted (near necrotic) zone.

摘要

在离体蛙心实验中，研究了高渗（3%）甘露醇溶液对（近坏死区）兴奋性恢复过程的影响，该影响是坏死组织对心室作用的结果。在对照实验中用林格液进行类似灌注。用林格液或甘露醇灌注心脏时，等电位S-T段恢复过程基本相同。心室机械图的同步记录显示甘露醇有明显的负性肌力作用。提示临床治疗缺血性疾病时所观察到的甘露醇的积极作用，与高渗溶液对梗死周边（近坏死）区细胞兴奋性的影响无关。