Kitaĭgorodskaia G M, Mukumov M R, Dmitrieva N V
Farmakol Toksikol. 1984 Jan-Feb;47(1):38-44.
Ouabain effects (5 X 10(-8)-5 X 10(-5) M) on the isometric contraction and intracellular action potentials were studied on frog atrial and ventricular muscles. It was found that ouabain produced a three-phase action on the electrical and contractile activity of the myocardium under different patterns of stimulation both in normal Ringer and D-600-containing solutions. The data suggest that the three-phase ouabain action is a consequence of its influence on at least two component processes of the excitation-contraction coupling in the frog heart muscle: the slow Na-Ca channels of the sarcolemma and Na+-K+ pump. The contribution of each mechanism depends on the glycoside concentration and the duration of exposure to ouabain.
研究了哇巴因（5×10⁻⁸ - 5×10⁻⁵ M）对青蛙心房和心室肌肉等长收缩及细胞内动作电位的影响。发现在正常任氏液和含D - 600的溶液中，在不同刺激模式下，哇巴因对心肌的电活动和收缩活动产生三相作用。数据表明，哇巴因的三相作用是其对青蛙心肌兴奋 - 收缩偶联的至少两个组成过程产生影响的结果：肌膜的慢钠 - 钙通道和钠 - 钾泵。每种机制的作用程度取决于糖苷浓度和暴露于哇巴因的持续时间。
