Fuks B B, Malaĭtsev V V, Bogdanova I M
Biull Eksp Biol Med. 1986 Jun;101(6):725-8.
The immune competence of C57Bl/6 mice implanted with EL-4 lymphoma of Lewis Lung carcinoma 3LL was investigated during 3 weeks after implantation. Splenic lymphocyte responses to mitogens (Con A, PHA, LPS, PWM) cytotoxic T lymphocytes (CTL) and interleukin-2 (IL-2) production were assessed. A dramatic reduction in mitogenic responses to Con A and PHA was observed during tumour progression. LPS and PWM responses were less depressed. Con A-induced IL-2 production correlated with Con A and PHA responses. Allospecific CTL response to mastocytoma P 815 was not decreased in syngeneic tumour-bearing mice.
在植入Lewis肺癌3LL的EL-4淋巴瘤后的3周内，对植入该淋巴瘤的C57Bl/6小鼠的免疫能力进行了研究。评估了脾淋巴细胞对丝裂原（刀豆蛋白A、植物血凝素、脂多糖、美洲商陆有丝分裂原）的反应、细胞毒性T淋巴细胞（CTL）以及白细胞介素-2（IL-2）的产生。在肿瘤进展过程中，观察到对刀豆蛋白A和植物血凝素的促有丝分裂反应显著降低。对脂多糖和美洲商陆有丝分裂原的反应降低程度较小。刀豆蛋白A诱导的IL-2产生与刀豆蛋白A和植物血凝素反应相关。在同基因荷瘤小鼠中，对肥大细胞瘤P 815的同种特异性CTL反应并未降低。
