定义阻碍选择的因素。
Defining Barriers that Impede Choices.
机构信息
Department of Microbiology and Immunology, University of Maryland School of Medicine, Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD 21201, USA.
Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
出版信息
Immunity. 2019 Mar 19;50(3):542-544. doi: 10.1016/j.immuni.2019.02.021.
Committing to a differentiation pathway means leaving alternative pathways behind. Adoue et al. (2019) report that the H3K9-methyltrasferase Setdb1 plays a role in inhibiting the Th1 program in committed Th2 cells, and mechanistically, its role might relate to the selective targeting of endogenous retroviruses adjacent to Th1 enhancers.
承诺走一条分化途径意味着要放弃其他途径。Adoue 等人（2019 年）报告称，H3K9-甲基转移酶 Setdb1 在抑制已分化的 Th2 细胞中的 Th1 程序中发挥作用，从机制上讲，其作用可能与选择性靶向 Th1 增强子附近的内源性逆转录病毒有关。
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