Liu Peng Ju, Ma Fang, Zhu Yan Ning, Lou Hui Ping
Department of Clinical Nutrition, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing, PR China.
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, China Academic Medical Science and Peking Union Medical College, Beijing, PR China.
Asia Pac J Clin Nutr. 2019;28(1):23-30. doi: 10.6133/apjcn.201903_28(1).0004.
To analyze the potential of fatty liver index (FLI) and several obesity indices and to explore which index is best for predicting nonalcoholic fatty liver disease (NAFLD) in Chinese postmenopausal women.
A cross-sectional study was conducted in 680 Chinese postmenopausal women. NAFLD was defined as a hepatic steatosis observed on liver ultrasonography in the absence of a second cause. Odds ratio and corresponding 95% confidence interval (CI) between hepatic steatosis and FLI as well as different obesity indices were evaluated by Binary Logistic regression model. Receiver operating characteristic curve and area under curve (AUC) were used to compare the ability of predicting hepatic steatosis between FLI and obesity indices.
The upper values of all indices were significantly associated with the presence of hepatic steatosis (all p<0.01) after the adjustment for potential confounders. The largest AUC [0.85 (0.82-0.88), 95% CI, p<0.01] was observed for FLI, followed by the frequently used obesity indices.
FLI is closely associated with the presence of hepatic steatosis in Chinese postmenopausal women. Compared to the obesity indices frequently used, FLI is a better surrogate marker for predicting the presence of hepatic steatosis in Chinese postmenopausal women.
分析脂肪肝指数（FLI）及几种肥胖指数的潜力，探讨哪种指数最适合预测中国绝经后女性的非酒精性脂肪性肝病（NAFLD）。
对680名中国绝经后女性进行了一项横断面研究。NAFLD定义为在肝脏超声检查中观察到的肝脂肪变性，且不存在其他病因。采用二元Logistic回归模型评估肝脂肪变性与FLI以及不同肥胖指数之间的优势比和相应的95%置信区间（CI）。使用受试者工作特征曲线和曲线下面积（AUC）来比较FLI和肥胖指数预测肝脂肪变性的能力。
在对潜在混杂因素进行调整后，所有指数的上限值均与肝脂肪变性的存在显著相关（所有p<0.01）。FLI的AUC最大[0.85（0.82 - 0.88），95% CI，p<0.01]，其次是常用的肥胖指数。
FLI与中国绝经后女性肝脂肪变性的存在密切相关。与常用的肥胖指数相比，FLI是预测中国绝经后女性肝脂肪变性存在的更好替代指标。
