Department of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
Department of Endocrinology, Auckland District Health Board, Auckland, New Zealand.
J Clin Endocrinol Metab. 2019 Aug 1;104(8):3576-3584. doi: 10.1210/jc.2019-00111.
Calcium intakes are commonly lower than the recommended levels, and increasing calcium intake is often recommended for bone health.
To determine the relationship between dietary calcium intake and rate of bone loss in older postmenopausal women.
Analysis of observational data collected from a randomized controlled trial. Participants were osteopenic (hip T-scores between -1.0 and -2.5) women, aged >65 years, not receiving therapy for osteoporosis nor taking calcium supplements. Women from the total cohort (n = 1994) contributed data to the analysis of calcium intake and bone mineral density (BMD) at baseline, and women from the placebo group (n = 698) contributed data to the analysis of calcium intake and change in BMD. BMD and bone mineral content (BMC) of the spine, total hip, femoral neck, and total body were measured three times over 6 years.
Mean calcium intake was 886 mg/day. Baseline BMDs were not related to quintile of calcium intake at any site, before or after adjustment for baseline age, height, weight, physical activity, alcohol intake, smoking status, and past hormone replacement use. There was no relationship between bone loss and quintile of calcium intake at any site, with or without adjustment for covariables. Total body bone balance (i.e., change in BMC) was unrelated to an individuals' calcium intake (P = 0.99).
Postmenopausal bone loss is unrelated to dietary calcium intake. This suggests that strategies to increase calcium intake are unlikely to impact the prevalence of and morbidity from postmenopausal osteoporosis.
钙的摄入量通常低于推荐水平，因此常建议增加钙的摄入量以维护骨骼健康。
确定绝经后老年女性的膳食钙摄入量与骨丢失率之间的关系。
对一项随机对照试验中收集的观察性数据进行分析。参与者为骨量减少（髋部 T 评分在-1.0 到-2.5 之间）、年龄＞65 岁、未接受骨质疏松症治疗且未服用钙补充剂的女性。来自总队列的女性（n=1994）为基线时钙摄入量和骨密度（BMD）分析提供了数据，来自安慰剂组的女性（n=698）为钙摄入量和 BMD 变化分析提供了数据。6 年内共 3 次测量了脊柱、全髋、股骨颈和全身的 BMD 和骨矿物质含量（BMC）。
平均钙摄入量为 886mg/天。基线 BMD 与任何部位的钙摄入量五分位数均无相关性，无论是否在调整基线年龄、身高、体重、体力活动、酒精摄入量、吸烟状况和既往激素替代使用后。任何部位的骨丢失与钙摄入量五分位数之间均无相关性，无论是否调整了协变量。个体钙摄入量与全身骨平衡（即 BMC 的变化）无关（P=0.99）。
绝经后骨丢失与膳食钙摄入量无关。这表明增加钙摄入量的策略不太可能影响绝经后骨质疏松症的患病率和发病率。
