University College London, London, United Kingdom.
* Eamon McCrory and Mattia Indi Gerin are also affiliated with Anna Freud National Centre for Children and Families, London, UK.
Child Maltreat. 2019 Nov;24(4):435-451. doi: 10.1177/1077559519830524. Epub 2019 Mar 21.
Childhood maltreatment is associated with a lifetime increase in risk of mental health disorder. We propose that such vulnerability may stem in large part from altered patterns of social functioning. Here, we highlight key findings from the psychological and epidemiological literature indicating that early maltreatment experience compromises social functioning and attenuates social support in ways that increase mental health vulnerability. We then review the extant neuroimaging studies of children and adolescents, focusing on three domains implicated in social functioning: threat processing, reward processing, and emotion regulation. We discuss how adaptations in these domains may increase latent vulnerability to mental health problems by impacting on social functioning via increased as well as increased . Finally, we explore how computational psychiatry approaches, alongside systematically reported measures of social functioning, can complement studies of neural function in the creation of a mechanistic framework aimed at informing approaches to prevention and intervention.
童年期虐待与心理健康障碍终生风险增加有关。我们提出，这种脆弱性可能在很大程度上源于社交功能模式的改变。在这里，我们重点介绍了心理学和流行病学文献中的关键发现，这些发现表明，早期的虐待经历会损害社交功能，并以削弱社会支持的方式增加心理健康的脆弱性。然后，我们回顾了现有的儿童和青少年神经影像学研究，重点关注三个与社交功能相关的领域：威胁处理、奖励处理和情绪调节。我们讨论了这些领域的适应性如何通过增加 和增加 来影响社交功能，从而通过增加潜在的心理健康问题的脆弱性。最后，我们探讨了计算精神病学方法如何与系统报告的社交功能措施相结合，以补充神经功能研究，为预防和干预措施提供信息，从而创建一个机械框架。
