Thomason Moriah E, Hendrix Cassandra L
Department of Child and Adolescent Psychiatry, New York University Medical Center, New York, NY, USA.
Department of Population Health, New York University Medical Center, New York, NY, USA.
Annu Rev Dev Psychol. 2024 Dec;6:87-107. doi: 10.1146/annurev-devpsych-120321-011905. Epub 2024 Sep 11.
This review summarizes recent findings on stress-related programming of brain development , with an emphasis on situating findings within the mothers' broader psychosocial experiences. Meta-analyses of observational studies on prenatal stress exposure indicate the direction and size of effects on child neurodevelopment are heterogeneous across studies. Inspired by lifespan and topological frameworks of adversity, we conceptualize individual variation in mothers' lived experience during and prior to pregnancy as a key determinant of these heterogeneous effects across populations. We structure our review to discuss experiential categories that may uniquely shape the psychological and biological influence of stress on pregnant mothers and their developing children, including current socioeconomic resources, exposure to chronic and traumatic stressors, culture and historical trauma, and the contours of prenatal stress itself. We conclude by identifying next steps that hold potential to meaningfully advance the field of fetal programming.
本综述总结了近期关于压力相关的大脑发育编程的研究结果，重点是将这些结果置于母亲更广泛的社会心理经历背景中。对产前压力暴露的观察性研究的荟萃分析表明，不同研究中对儿童神经发育的影响方向和程度存在异质性。受逆境的生命周期和拓扑框架启发，我们将母亲孕期及孕前生活经历的个体差异概念化为这些人群中异质性影响的关键决定因素。我们组织本综述来讨论可能独特地塑造压力对怀孕母亲及其发育中胎儿的心理和生物学影响的经历类别，包括当前的社会经济资源、接触慢性和创伤性应激源、文化和历史创伤，以及产前压力本身的概况。我们通过确定有可能切实推动胎儿编程领域发展的后续步骤来结束本文。
