1 The Warren Alpert Medical School of Brown University, Providence, RI, USA.
2 Emory University School of Medicine, Atlanta, GA, USA.
Integr Cancer Ther. 2019 Jan-Dec;18:1534735419835310. doi: 10.1177/1534735419835310.
Soy consumption in human diet has been linked to decreased incidence of a variety of cancers, suggesting a potential role of soy products in cancer prevention and control. Furthermore, a substantial body of evidence in the literature suggests that soy supplementation may improve the efficacy and prevent the adverse effects of cancer chemotherapy and radiation therapy. Isoflavones constitute the predominant anticancer bioactive compounds in soy. Genistein, which is the most abundant and active isoflavone in soy, has a multitude of effects on cancer cells, including inhibition of NF-κB activation and DNA methylation, enhancement of histone acetylation, inhibition of cell growth and metastasis, and antiangiogenic, anti-inflammatory, and anti-oxidant effects. Isoflavones are orally bioavailable, easily metabolized, and usually considered safe. In this article, we review in vitro and in vivo evidence as well as the results of clinical and epidemiological studies on the effects of soy isoflavones, with a focus on sensitization of cancer cells to chemotherapy and radiation while at the same time protecting normal cells from the harmful effects of these treatments.
大豆在人类饮食中的消费与各种癌症发病率的降低有关，这表明大豆制品在癌症的预防和控制中可能发挥作用。此外，大量文献证据表明，大豆补充剂可能提高癌症化疗和放疗的疗效并预防其不良反应。异黄酮是大豆中主要的抗癌生物活性化合物。大豆中含量最丰富、活性最强的异黄酮是染料木黄酮，它对癌细胞有多种作用，包括抑制 NF-κB 激活和 DNA 甲基化、增强组蛋白乙酰化、抑制细胞生长和转移以及抗血管生成、抗炎和抗氧化作用。异黄酮可口服生物利用，易代谢，通常被认为是安全的。本文综述了体外和体内证据以及临床和流行病学研究的结果，重点讨论了大豆异黄酮对癌细胞对化疗和放疗敏感性的作用，同时保护正常细胞免受这些治疗的有害影响。
