同种异型特异性抑制细胞的过继转移可抑制同基因无胸腺小鼠中不依赖胸腺的免疫球蛋白产生。
Adoptive transfer of allotype-specific suppressor cells inhibits thymus-independent immunoglobulin production in syngeneic athymic mice.
作者信息
Jacobson E B
出版信息
J Exp Med. 1978 Aug 1;148(2):607-12. doi: 10.1084/jem.148.2.607.
Abstract
(SJL X BALB)F1 suppressed mice have, in their lymphoid tissues, a population of suppressor T cells directed specifically against a paternal gamma G2a allotype (Ig-1b). Spleen or lymph node cells from these mice were injected into syngeneic nude mice and the effect on thymus-independent synthesis of Ig-1b in the athymic recipients was determined. After the injection of suppressor cells, Ig-1b disappeared from the serum of the recipients in a time course similar to that seen in normal mice. These results indicate that suppression occurs in the absence of thymus-derived helper cells, and they suggest that Ig-1b-producing B cells are the target of allotype-suppressor cells.
摘要
（SJL×BALB）F1抑制性小鼠在其淋巴组织中有一群特异性针对父本γG2a同种异型（Ig-1b）的抑制性T细胞。将这些小鼠的脾细胞或淋巴结细胞注射到同基因裸鼠体内，并测定对无胸腺受体中不依赖胸腺的Ig-1b合成的影响。注射抑制性细胞后，Ig-1b在受体血清中消失的时间进程与正常小鼠相似。这些结果表明，在没有胸腺来源的辅助性细胞的情况下也会发生抑制作用，并且提示产生Ig-1b的B细胞是同种异型抑制性细胞的靶标。
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本文引用的文献
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In vitro studies of allotype suppression in mice.小鼠同种异型抑制的体外研究。
Eur J Immunol. 1973 Oct;3(10):619-24. doi: 10.1002/eji.1830031005.
2
Immunoglobulin levels of sera of genetically thymusless (nude) mice.遗传性无胸腺（裸）小鼠血清的免疫球蛋白水平。
Eur J Immunol. 1973 Feb;3(2):117-8. doi: 10.1002/eji.1830030213.
3
Serum immunoglobulins and antibodies in congenitally athymic (nude) mice.先天性无胸腺（裸）小鼠的血清免疫球蛋白和抗体
Aust J Exp Biol Med Sci. 1972 Oct;50(5):625-35. doi: 10.1038/icb.1972.55.
4
Serum immunoglobulin levels in nude mice.裸鼠的血清免疫球蛋白水平。
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