自然感染婴儿利什曼原虫的犬泌尿系统血清生化参数、结构变化、免疫组织化学及寄生虫负荷的评估
Evaluation of Serum Biochemical Parameters, Structural Changes, Immunohistochemistry and Parasite Load in the Urinary System of Dogs Infected Naturally by Leishmania infantum.
作者信息
Silva J L, Oliveira V V G, Silva L A M T, E Silva R P, Alves L C, Cavalcanti M P, Júnior V A Silva
机构信息
Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros s/n, Dois Irmãos, Recife.
Centro Acadêmico de Vitória, Universidade Federal de Pernambuco, Rua Alto do Reservatório s/n, Bela Vista, Vitória de Santo Antão.
出版信息
J Comp Pathol. 2019 Feb;167:26-31. doi: 10.1016/j.jcpa.2018.11.007. Epub 2019 Jan 7.
The aim of this study was to evaluate the histopathological changes in the urinary system and their correlation with serum biochemical parameters, parasite load and immunodetection of amastigotes in 30 dogs infected naturally by Leishmania infantum. The major histological changes were glomerulonephritis and interstitial nephritis. Serum biochemistry demonstrated that the dogs had progressive loss of renal function. L. infantum amastigotes were detected immunohistochemically in all parts of the urinary system, except the ureters. There was a correlation between parasite load, severity of histopathological changes and immunodetection of the parasites, but parasite load was not correlated with the serum biochemical parameters evaluated.
本研究的目的是评估30只自然感染婴儿利什曼原虫的犬泌尿系统的组织病理学变化及其与血清生化参数、寄生虫负荷和无鞭毛体免疫检测的相关性。主要组织学变化为肾小球肾炎和间质性肾炎。血清生化检查表明，这些犬的肾功能逐渐丧失。除输尿管外，在泌尿系统的所有部位均通过免疫组织化学检测到婴儿利什曼原虫无鞭毛体。寄生虫负荷、组织病理学变化的严重程度与寄生虫的免疫检测之间存在相关性，但寄生虫负荷与所评估的血清生化参数无关。
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