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脑5'-脱氧-5'-甲硫腺苷磷酸化酶的区域模式及耐热性

Regional pattern and heat-resistance of brain 5'-deoxy-5'-methylthioadenosine phosphorylase.

作者信息

Abbruzzese A, Della Pietra G, Porta R

出版信息

Experientia. 1986 Jul 15;42(7):820-1. doi: 10.1007/BF01941537.

DOI:10.1007/BF01941537
PMID:3089834
Abstract

The distribution of 5'-deoxy-5'-methylthioadenosine (MTA) phosphorylase in 10 pig brain areas was determined. The observed regional differences of the enzymatic activity seem to reflect more the pattern of brain spermine distribution rather than that of spermidine. Moreover, comparative studies on the heat-resistance of MTA phosphorylase extracted from the whole brain of various species suggest structural differences in the enzyme molecules occurring in the brains of different animals.

摘要

测定了5'-脱氧-5'-甲硫基腺苷（MTA）磷酸化酶在猪脑10个区域中的分布。所观察到的酶活性区域差异似乎更多地反映了脑精胺的分布模式，而非亚精胺的分布模式。此外，对从不同物种全脑中提取的MTA磷酸化酶耐热性的比较研究表明，不同动物脑中的酶分子存在结构差异。

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Regional pattern and heat-resistance of brain 5'-deoxy-5'-methylthioadenosine phosphorylase.脑5'-脱氧-5'-甲硫腺苷磷酸化酶的区域模式及耐热性
Experientia. 1986 Jul 15;42(7):820-1. doi: 10.1007/BF01941537.
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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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OBSERVATIONS ON THE METABOLISM OF 5'-METHYLTHIOADENOSINE.关于5'-甲硫腺苷代谢的观察
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Trends in the biochemical pharmacology of 5'-deoxy-5'-methylthioadenosine.5'-脱氧-5'-甲硫基腺苷的生化药理学研究趋势
Biochem Pharmacol. 1982 Feb 1;31(3):277-88. doi: 10.1016/0006-2952(82)90171-x.
4
Structural analogs of 5'-methylthioadenosine as substrates and inhibitors of 5'-methylthioadenosine phosphorylase and as inhibitors of human lymphocyte transformation.5'-甲硫基腺苷的结构类似物作为5'-甲硫基腺苷磷酸化酶的底物和抑制剂以及人淋巴细胞转化的抑制剂。
Biochem Pharmacol. 1982 Feb 15;31(4):503-7. doi: 10.1016/0006-2952(82)90151-4.
5
Occurrence of 5'-deoxy-5'-methylthioadenosine phosphorylase in the mammalian CNS: distribution and kinetic studies on the rat brain enzyme.
J Neurochem. 1983 Feb;40(2):487-92. doi: 10.1111/j.1471-4159.1983.tb11309.x.
6
5'-Methylthioadenosine phosphorylase-L. Substrate activity of 5'-deoxyadenosine with the enzyme from Sarcoma 180 cells.5'-甲硫基腺苷磷酸化酶-L。5'-脱氧腺苷与肉瘤180细胞来源的该酶的底物活性。
Biochem Pharmacol. 1981 Feb 1;30(3):189-99. doi: 10.1016/0006-2952(81)90077-0.
7
Phosphate-stimulated breakdown of 5'-methylthioadenosine by rat ventral prostate.磷酸盐刺激大鼠腹侧前列腺对5'-甲硫腺苷的分解代谢
Biochem J. 1969 Nov;115(2):241-7. doi: 10.1042/bj1150241.
8
Studies on phosphate-activated 5'-methylthioadenosine nucleosidase from human placenta.人胎盘磷酸激活的5'-甲硫腺苷核苷酶的研究。
Int J Biochem. 1978;9(1):35-41. doi: 10.1016/0020-711x(78)90135-0.
9
Demonstration of 5'-methylthioadenosine phosphorylase activity in various rat tissues. Some properties of the enzyme from rat lung.大鼠多种组织中5'-甲硫腺苷磷酸化酶活性的测定。大鼠肺脏中该酶的某些特性。
Biochim Biophys Acta. 1978 Mar 14;523(1):82-93. doi: 10.1016/0005-2744(78)90011-6.
10
Substrate specificity of 5'-methylthioadenosine phosphorylase from human prostate.人前列腺5'-甲硫腺苷磷酸化酶的底物特异性
Biochem J. 1978 Dec 1;175(3):1043-50. doi: 10.1042/bj1751043.