基于韩国全国健康和营养调查的青少年及其母亲的血脂谱之间的关联。

Associations between lipid profiles of adolescents and their mothers based on a nationwide health and nutrition survey in South Korea.

机构信息

Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea (the Republic of).

Department of Medicine, Graduate School, Yonsei University, Seoul, Korea (the Republic of).

出版信息

BMJ Open. 2019 Mar 20;9(3):e024731. doi: 10.1136/bmjopen-2018-024731.

DOI:10.1136/bmjopen-2018-024731

PMID:30898813

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6475165/

Abstract

OBJECTIVES

Dyslipidaemia is a metabolic disease influenced by environmental and genetic factors. Especially, family history related to genetic background is a strong risk factor of lipid abnormality. The aim of this study is to evaluate the association between the lipid profiles of adolescents and their mothers.

DESIGN

A cross-sectional study.

SETTING

The data were derived from the Korea National Health and Nutrition Examination Survey (IV-VI) between 2009 and 2015.

PARTICIPANTS

2884 adolescents aged 12-18 years and their mothers were included.

PRIMARY OUTCOME MEASURES

Outcome variables were adolescents' lipid levels. Mothers' lipid levels were the interesting variables. The lipid profiles included total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We identified partial correlation coefficients () between the lipids. Multiple linear regressions were performed to identify the amount of change in adolescents' lipid levels for each unit increase of their mothers' lipids. The regression models included various clinical characteristics and health behavioural factors of both adolescents and mothers.

RESULTS

The mean levels of adolescents' lipids were 156.6, 83.6, 50.4 and 89.4 mg/dL, respectively for TC, TG, HDL-C and LDL-C. Positive correlations between lipid levels of adolescents and mothers were observed for TC, TG, HDL-C and LDL-C ( 95% CI: 0.271, 0.236 to 0.304; 0.204, 0.169 to 0.239; 0.289, 0.255 to 0.322; and 0.286, 0.252 to 0.319). The adolescent TC level was increased by 0.23 mg/dL for each unit increase of the mother's TC (SE, 0.02; p<0.001). The beta coefficients were 0.16 (SE, 0.01), 0.24 (SE, 0.02) and 0.24 (SE, 0.02), respectively, in each model of TG, HDL-C and LDL-C (all p<0.001). The linear relationships were significant regardless of sex and mother's characteristics.

CONCLUSIONS

Mothers' lipid levels are associated with adolescents' lipids; therefore, they can serve as a reference for the screening of adolescent's dyslipidaemia.

摘要

目的

血脂异常是一种受环境和遗传因素影响的代谢性疾病。特别是，与遗传背景相关的家族史是脂质异常的一个强烈危险因素。本研究旨在评估青少年血脂水平与其母亲之间的关联。

设计

横断面研究。

地点

数据来自于 2009 年至 2015 年期间的韩国国家健康和营养检查调查（IV-VI）。

参与者

共纳入 2884 名 12-18 岁的青少年及其母亲。

主要结局测量指标

结局变量为青少年的血脂水平。母亲的血脂水平是感兴趣的变量。血脂谱包括总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）。我们确定了青少年和母亲之间血脂之间的部分相关系数（r）。进行多元线性回归以确定母亲的血脂每增加一个单位，青少年的血脂水平变化的量。回归模型包括青少年和母亲的各种临床特征和健康行为因素。

结果

青少年血脂的平均水平分别为 TC156.6、TG83.6、HDL-C50.4 和 LDL-C89.4mg/dL。青少年和母亲的血脂水平之间存在 TC、TG、HDL-C 和 LDL-C 的正相关（r95%CI：0.271、0.236 至 0.304；0.204、0.169 至 0.239；0.289、0.255 至 0.322；0.286、0.252 至 0.319）。母亲 TC 每增加一个单位，青少年的 TC 水平增加 0.23mg/dL（SE，0.02；p<0.001）。β系数分别为 TG 的 0.16（SE，0.01）、HDL-C 的 0.24（SE，0.02）和 LDL-C 的 0.24（SE，0.02）（均 p<0.001）。在每个 TG、HDL-C 和 LDL-C 的模型中，线性关系均具有统计学意义，无论性别和母亲的特征如何。