Department of Pharmaceutical Medicine and Regulatory Sciences, Colleges of Medicine and Pharmacy, Seoul, Republic of Korea; Department of Korean Medicine, Research Center of Korean Medicine, Colleges of Dongguk University, Kyungsangbukdo, Republic of Korea.
Department of Pharmacy, College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, South Korea.
J Clin Lipidol. 2018 Mar-Apr;12(2):437-446. doi: 10.1016/j.jacl.2018.01.009. Epub 2018 Jan 31.
The prevalence of dyslipidemia, particularly hypercholesterolemia, has been reported to increase after pregnancy and menopause in Korea. This suggests the importance of the management of dyslipidemia in women for preventing cardiovascular diseases.
This study aimed to examine the association of breastfeeding with 5 subtypes of dyslipidemia in Korean women aged over 20 years, by using the nationally representative Korea National Health and Nutrition Examination Survey 2010-2014.
Ordinary least square regression and ordered logistic regression analyses were used to determine the association between breastfeeding duration and dyslipidemia.
The likelihood of having low-density lipoprotein cholesterol (LDL-C) disorder decreased by 16% in the group that breastfed for more than 24 months (odds ratio, 0.84; 95% confidence interval, 0.75-0.95) compared with the group that did not breastfeed. The likelihood of having non-high-density lipoprotein cholesterol (non-HDL-C) disorder was significantly reduced by 25% when the breastfeeding duration was more than 24 months (odds ratio, 0.75; 95% confidence interval, 0.64-0.87). The tendency toward developing disorders of total cholesterol (TC), LDL-C, and non-HDL-C decreased as the duration of breastfeeding increased, particularly among women aged 30-39 years.
Breastfeeding duration was negatively correlated with dyslipidemia in terms of TC, LDL-C, non-HDL-C, and triglycerides. Long-term breastfeeding was associated with the prevalence of dyslipidemia-TC, LDL-C, non-HDL-C, and TG disorders, in particular.
据报道,在韩国,血脂异常(尤其是高胆固醇血症)的患病率在怀孕和绝经后会增加。这表明在女性中管理血脂异常对于预防心血管疾病非常重要。
本研究旨在利用 2010-2014 年韩国全国健康和营养调查的数据,研究母乳喂养与韩国 20 岁以上女性 5 种血脂异常亚型之间的关联。
使用普通最小二乘法回归和有序逻辑回归分析来确定母乳喂养时间与血脂异常之间的关联。
与未母乳喂养的女性相比,母乳喂养时间超过 24 个月的女性发生低密度脂蛋白胆固醇(LDL-C)异常的可能性降低了 16%(比值比,0.84;95%置信区间,0.75-0.95)。母乳喂养时间超过 24 个月时,非高密度脂蛋白胆固醇(non-HDL-C)异常的可能性显著降低了 25%(比值比,0.75;95%置信区间,0.64-0.87)。随着母乳喂养时间的延长,TC、LDL-C 和 non-HDL-C 发生异常的可能性呈下降趋势,尤其是在 30-39 岁的女性中。
母乳喂养时间与 TC、LDL-C、non-HDL-C 和甘油三酯的血脂异常呈负相关。母乳喂养时间与血脂异常-TC、LDL-C、non-HDL-C 和甘油三酯异常的发生率相关,尤其是长期母乳喂养。