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巨大后颅窝脑膜瘤:早期诊断的重要性及治疗挑战

Giant posterior fossa meningioma: the importance of early diagnosis and challenges concerning treatment.

作者信息

Antunes Cristiano, Ramos Rui, Machado Maria João, Filipe Miguel Afonso

机构信息

Neurosurgery, Hospital de Braga, Braga, Portugal.

出版信息

BMJ Case Rep. 2019 Mar 20;12(3):e228454. doi: 10.1136/bcr-2018-228454.

Abstract

Posterior fossa lesions may present with behavioural changes and/or progressive neurological deficit. Patients may have symptoms for long periods which may be attributed to other causes such as psychiatric diseases. We report a case of a 44-year-old woman with behavioural changes lasting for 5 years who lost her job, marriage and the guard of her sons. Latterly, she developed neurological deficit, hydrocephalus and intracranial hypertension. A giant left pontocerebellar angle mass was diagnosed. A retrosigmoid craniotomy was performed with total removal and cranial nerve function's preservation. Histology revealed a grade I meningioma. The surgical approach for such huge lesions on pontocerebellar angle is controversial concerning patient's positioning and surgical route. A brief revision is made. Since nowadays medical imaging is more easily accessible, it is mandatory to have a brain image in patients with behavioural changes and/or neurological deficit to exclude potential structural and curable causes such as in this case.

摘要

后颅窝病变可能表现为行为改变和/或进行性神经功能缺损。患者可能长期出现症状,这些症状可能归因于其他原因,如精神疾病。我们报告一例44岁女性,其行为改变持续5年,导致失业、婚姻破裂并失去对儿子的监护权。后来,她出现了神经功能缺损、脑积水和颅内高压。诊断为左侧桥小脑角巨大肿物。行乙状窦后开颅术,实现全切除并保留了颅神经功能。组织学检查显示为I级脑膜瘤。对于桥小脑角如此巨大的病变,手术入路在患者体位和手术路径方面存在争议。本文进行简要回顾。由于如今医学影像更容易获取,对于有行为改变和/或神经功能缺损的患者,必须进行脑部影像检查,以排除潜在的结构性和可治愈病因,如此病例所示。

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