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本文引用的文献

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Tertiary Lymphoid Organs in Central Nervous System Autoimmunity.中枢神经系统自身免疫中的三级淋巴器官。
Front Immunol. 2016 Oct 25;7:451. doi: 10.3389/fimmu.2016.00451. eCollection 2016.
2
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J Rheumatol. 2014 Nov;41(11):2214-22. doi: 10.3899/jrheum.131527. Epub 2014 Oct 1.
3
The International Classification of Headache Disorders, 3rd edition (beta version).《国际头痛疾病分类》第三版（试用版）
Cephalalgia. 2013 Jul;33(9):629-808. doi: 10.1177/0333102413485658.
4
Dysregulation of germinal centres in autoimmune disease.自身免疫性疾病中生发中心的失调。
Nat Rev Immunol. 2009 Dec;9(12):845-57. doi: 10.1038/nri2637.
5
Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group.干燥综合征分类标准：欧美共识小组提出的欧洲标准修订版。
Ann Rheum Dis. 2002 Jun;61(6):554-8. doi: 10.1136/ard.61.6.554.
6
Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE.SLEDAI的推导。狼疮患者的疾病活动指数。系统性红斑狼疮预后研究委员会。
Arthritis Rheum. 1992 Jun;35(6):630-40. doi: 10.1002/art.1780350606.

鞘内注射利妥昔单抗治疗原发性干燥综合征的严重头痛

Severe headache in primary Sjögren's syndrome treated with intrathecal rituximab.

作者信息

Tjensvoll Anne Bolette, Lauvsnes Maria Boge, Norheim Katrine Brekke, Omdal Roald

机构信息

Department of Neurology Stavanger University Hospital Stavanger Norway.

Department of Internal Medicine Stavanger University Hospital Stavanger Norway.

出版信息

Clin Case Rep. 2019 Jan 17;7(3):416-418. doi: 10.1002/ccr3.1987. eCollection 2019 Mar.

DOI:10.1002/ccr3.1987
PMID:30899462
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6406134/
Abstract

A severe and persistent migrainous headache in a patient with primary Sjøgren's syndrome unresponsive to treatment with immunosuppressive drugs, triptans, opioids, and NSAIDs, responded successfully to intrathecal B-cell depletion with rituximab. We hypothesize that brain-resident autoreactive B cells were involved in headache pathogenesis and were eliminated by this procedure.

摘要

一名原发性干燥综合征患者出现严重且持续性偏头痛，对免疫抑制药物、曲坦类药物、阿片类药物及非甾体抗炎药治疗均无反应，鞘内注射利妥昔单抗进行B细胞清除治疗后取得成功。我们推测脑内自身反应性B细胞参与了头痛的发病机制，并通过该治疗过程被清除。