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非急性早幼粒细胞白血病变异型,伴有t(11;17)的急性髓系白血病

Non-acute promyelocytic leukemia variant, acute myeloid leukemia with translocation (11;17).

作者信息

Altahan Rahaf, Altahan Shatha, Khalil Salem

机构信息

Hematology Unit, Department of Pathology and Laboratory Medicine King Faisal Specialist Hospital and Research Center Riyadh Saudi Arabia.

Hematology Unit, Department of Pathology and Laboratory Medicine King Khalid University Hospital Riyadh Saudi Arabia.

出版信息

Clin Case Rep. 2019 Feb 10;7(3):558-563. doi: 10.1002/ccr3.2044. eCollection 2019 Mar.

Abstract

t(11;17) is a rare but recognized finding usually found in Acute Promyelocytic Leukemia with variant translocation (APLv). We present a case of Acute Myeloid Leukemia with t(11;17) that has different break points than those occurring in APLv. The diagnosis of acute myeloid leukemia, not otherwise specified, acute monoblastic leukemia was reached after a thorough investigation. Reaching the correct diagnosis and distinguishing these two entities are essential as they have different management, prognosis, and overall survival.

摘要

t(11;17)是一种罕见但已被认可的发现,通常见于伴有变异易位的急性早幼粒细胞白血病(APLv)。我们报告一例患有t(11;17)的急性髓系白血病病例,其断点与APLv中出现的断点不同。经过全面检查,最终诊断为未另行指定的急性髓系白血病、急性单核细胞白血病。做出正确诊断并区分这两种实体至关重要,因为它们的治疗、预后和总生存期各不相同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ff02/6406162/0d423f94940b/CCR3-7-558-g001.jpg

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