Caliskan Selahattin, Kaba Selçuk, Özsoy Emrah, Keleş Muzaffer Oğuz, Koca Orhan, Akyüz Mehmet, Karaman Muhammet Ihsan
Department of Urology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
J Cancer Res Ther. 2019 Mar;15(Supplement):S47-S50. doi: 10.4103/0973-1482.187290.
Metabolic syndrome (MetS) is an abnormality that increases the risk of cardiovascular disease and diabetes. In the recent years, studies showed that MetS is associated with increased risk of incidence, aggressiveness, and mortality of prostate cancer (PCa). We examined the influence of MetS at final pathology in Turkish patients with PCa.
MetS was defined according to the American Heart Association, National Heart, Lung, Blood Institute, and International Diabetes Federation and requires any three of five components. The patients without and with MetS were in Group 1 and 2, respectively. Data were compared with independent sample t-test and Chi-squared test.
There were 117 patients in the study. The patients' age was between 51 and 77 years with a median of 64.87 ± 5.65 and 62.29 ± 5.57, and prostate-specific antigen (PSA) level of the patients was 8.19 ± 5.35 and 8.68 ± 2.22 ng/ml in Group 1 and 2. Of these patients; Group 1 and 2 had 86 and 31 patients. High-grade PCa (Gleason >7) and advanced PCa (T3, T4) at final pathology were reported in 44.18-18.60% and 38.70-32.25% in Group 1 and 2.
The patients with MetS are diagnosed significantly younger and had higher PSA levels than the other patients. Advanced disease of PCa is seen much more in patients with MetS.
代谢综合征（MetS）是一种会增加心血管疾病和糖尿病风险的异常情况。近年来，研究表明MetS与前列腺癌（PCa）发病率、侵袭性和死亡率增加的风险相关。我们研究了MetS对土耳其PCa患者最终病理结果的影响。
根据美国心脏协会、美国国立心肺血液研究所和国际糖尿病联盟的标准定义MetS，需要满足五个组成部分中的任意三个。无MetS和有MetS的患者分别为第1组和第2组。数据采用独立样本t检验和卡方检验进行比较。
本研究共有117例患者。患者年龄在51至77岁之间，第1组和第2组的中位数分别为64.87±5.65岁和62.29±5.57岁，患者的前列腺特异性抗原（PSA）水平分别为8.19±5.35 ng/ml和8.68±2.22 ng/ml。在这些患者中，第1组和第2组分别有86例和31例患者。最终病理报告显示，第1组和第2组中高级别PCa（Gleason评分>7）和晚期PCa（T3、T4）的比例分别为44.18% - 18.60%和38.70% - 32.25%。
患有MetS的患者被诊断时明显比其他患者年轻，且PSA水平更高。MetS患者中PCa的晚期疾病更为常见。
