Department of Life Science & Bioinformatics, Assam University, Silchar 788011, India.
Department of Life Science & Bioinformatics, Assam University, Silchar 788011, India.
Med Hypotheses. 2019 Apr;125:119-123. doi: 10.1016/j.mehy.2019.01.006. Epub 2019 Jan 11.
Immunity to Plasmodium falciparum is contributed by many known and unknown factors. Lack of effective vaccine and rise in drug-resistant Plasmodium parasites leads to the major challenge in controlling the parasite. Determination of surface or secreted proteins which are essential for the survival of the pathogen is a very important step in finding potential vaccine candidates. Despite the discovery of several vaccine candidates against Plasmodium over the last decades, an effective vaccine is not available. The present study hypothesized that the PRE-binding protein (PREBP) could be a potential vaccine candidate against malaria pathogenesis. PREBP is highly conserved among the class Aconoidasida and exhibit high antigenicity and accessibility as a secretory protein. The present hypothesis was tested by employing in-silico translational genomics wherein the antigenicity, localization and the conservancy were determined.
疟原虫的免疫是由许多已知和未知的因素共同贡献的。缺乏有效的疫苗和抗药性疟原虫的出现给寄生虫的控制带来了重大挑战。确定对病原体的生存至关重要的表面或分泌蛋白是寻找潜在疫苗候选物的重要步骤。尽管在过去几十年中发现了几种针对疟原虫的疫苗候选物，但仍没有有效的疫苗。本研究假设 PRE 结合蛋白 (PREBP) 可能是一种针对疟疾发病机制的潜在疫苗候选物。PREBP 在 Aconoidasida 类中高度保守，表现出作为分泌蛋白的高抗原性和可及性。本研究通过采用计算机翻译基因组学来检验这一假说，其中确定了抗原性、定位和保守性。
