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远程监测植入式心脏转复除颤器和再同步装置以改善患者预后:死胡同还是前进的道路?

Remote monitoring of implantable cardioverter-defibrillators and resynchronization devices to improve patient outcomes: dead end or way ahead?

机构信息

Heart and Vascular Theme, Karolinska University Hospital, Stockholm, Sweden.

Department of Cardiology and Pneumology, Innovative Clinical Trials, University Medical Centre Göttingen, Göttingen, Germany.

出版信息

Europace. 2019 Jun 1;21(6):846-855. doi: 10.1093/europace/euz011.

Abstract

Remote monitoring (RM) has become a new standard of care in the follow-up of patients with implantable pacemakers and defibrillators. While it has been consistently shown that RM enables earlier detection of clinically actionable events compared with traditional in-patient evaluation, this advantage did not translate into improved patient outcomes in clinical trials of RM except one study using daily multiparameter telemonitoring in heart failure (HF) patients. Therefore, this review, focusing on RM studies of implantable cardioverter-defibrillators and cardiac resynchronization therapy defibrillators in patients with HF, discusses possible explanations for the differences in trial outcomes. Patient selection may play an important role as more severe HF and concomitant atrial fibrillation have been associated with improved outcomes by RM. Furthermore, the technical set-up of RM may have an important impact as a higher level of connectivity with more frequent data transmission can be linked to better outcomes. Finally, there is growing evidence as to the need of effective algorithms ensuring a fast and well-structured clinical response to the events detected by RM. These factors re-emphasize the potential of remote management of device patients with HF and call for continued clinical research and technical development in the field.

摘要

远程监测 (RM) 已成为植入式起搏器和除颤器患者随访的新标准。虽然已经一致表明,与传统的住院评估相比,RM 能够更早地检测到具有临床意义的事件,但这种优势并未在 RM 的临床试验中转化为改善患者结局,除了一项使用心力衰竭 (HF) 患者每日多参数远程监测的研究。因此,本综述重点关注 HF 患者植入式心脏复律除颤器和心脏再同步治疗除颤器的 RM 研究,讨论了试验结果差异的可能解释。患者选择可能起着重要作用,因为更严重的 HF 和伴发的心房颤动与 RM 带来的改善结局相关。此外,RM 的技术设置可能具有重要影响,因为与更频繁的数据传输相关的更高水平的连接性可以与更好的结局相关联。最后,有越来越多的证据表明,需要有效的算法来确保对 RM 检测到的事件进行快速和结构良好的临床响应。这些因素再次强调了 HF 患者远程管理设备的潜力,并呼吁在该领域继续进行临床研究和技术开发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bedc/6545502/dbf0ffbfa5c8/euz011f1.jpg

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