血管生成过程中的内皮尖端细胞-柄细胞选择与重排
The endothelial tip-stalk cell selection and shuffling during angiogenesis.
作者信息
Chen Wenqi, Xia Peng, Wang Heping, Tu Jihao, Liang Xinyue, Zhang Xiaoling, Li Lisha
机构信息
The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, China.
Department of Anesthesia, Jilin Provincial People's Hospital, Changchun, China.
出版信息
J Cell Commun Signal. 2019 Sep;13(3):291-301. doi: 10.1007/s12079-019-00511-z. Epub 2019 Mar 22.
Abstract
Angiogenesis is a critical, fine-tuned, multi-staged biological process. Tip-stalk cell selection and shuffling are the building blocks of sprouting angiogenesis. Accumulated evidences show that tip-stalk cell selection and shuffling are regulated by a variety of physical, chemical and biological factors, especially the interaction among multiple genes, their products and environments. The classic Notch-VEGFR, Slit-Robo, ECM-binding integrin, semaphorin and CCN family play important roles in tip-stalk cell selection and shuffling. In this review, we outline the progress and prospect in the mechanism and the roles of the various molecules and related signaling pathways in endothelial tip-stalk cell selection and shuffling. In the future, the regulators of tip-stalk cell selection and shuffling would be the potential markers and targets for angiogenesis.
摘要
血管生成是一个关键的、精细调节的多阶段生物学过程。尖端细胞与柄细胞的选择及转换是出芽血管生成的基础。越来越多的证据表明，尖端细胞与柄细胞的选择及转换受多种物理、化学和生物学因素调控，尤其是多个基因及其产物与环境之间的相互作用。经典的Notch-VEGFR、Slit-Robo、细胞外基质结合整合素、信号素和CCN家族在尖端细胞与柄细胞的选择及转换中发挥重要作用。在本综述中，我们概述了各种分子及其相关信号通路在内皮尖端细胞与柄细胞选择及转换中的机制和作用方面的进展与前景。未来，尖端细胞与柄细胞选择及转换的调节因子将成为血管生成的潜在标志物和靶点。
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本文引用的文献
1
CCN proteins as potential actionable targets in scleroderma.CCN 蛋白作为硬皮病的潜在治疗靶点。
Exp Dermatol. 2019 Jan;28(1):11-18. doi: 10.1111/exd.13806. Epub 2018 Dec 11.
2
Filopodia and focal adhesions: An integrated system driving branching morphogenesis in neuronal pathfinding and angiogenesis.丝状伪足和黏着斑：一个整合系统，推动神经元导向和血管生成中的分支形态发生。
Dev Biol. 2019 Jul 1;451(1):86-95. doi: 10.1016/j.ydbio.2018.08.015. Epub 2018 Sep 5.
3
How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors.内皮细胞如何调整其代谢以在肿瘤中形成血管。
Front Immunol. 2017 Dec 11;8:1750. doi: 10.3389/fimmu.2017.01750. eCollection 2017.
4
A Network Model to Explore the Effect of the Micro-environment on Endothelial Cell Behavior during Angiogenesis.一种用于探究微环境在血管生成过程中对内皮细胞行为影响的网络模型。
Front Physiol. 2017 Nov 27;8:960. doi: 10.3389/fphys.2017.00960. eCollection 2017.
5
Endothelial Cell Metabolism.内皮细胞代谢
Physiol Rev. 2018 Jan 1;98(1):3-58. doi: 10.1152/physrev.00001.2017.
6
Do as I say, Not(ch) as I do: Lateral control of cell fate.照我说的做，而非照我做的做：细胞命运的侧向控制
Dev Biol. 2019 Mar 1;447(1):58-70. doi: 10.1016/j.ydbio.2017.09.032. Epub 2017 Sep 29.
7
Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk tip cell competence.骨形态发生蛋白在发芽血管生成中的作用：不同的骨形态发生蛋白受体依赖性信号通路平衡茎尖细胞能力。
FASEB J. 2017 Nov;31(11):4720-4733. doi: 10.1096/fj.201700193RR. Epub 2017 Jul 21.
8
Dll4 and Notch signalling couples sprouting angiogenesis and artery formation.Dll4 和 Notch 信号通路耦连出芽型血管生成和动脉形成。
Nat Cell Biol. 2017 Aug;19(8):915-927. doi: 10.1038/ncb3555. Epub 2017 Jul 17.
9
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Biomaterials. 2017 Oct;141:314-329. doi: 10.1016/j.biomaterials.2017.07.010. Epub 2017 Jul 7.
10
Glutamine fuels proliferation but not migration of endothelial cells.谷氨酰胺为内皮细胞的增殖提供能量，但不支持其迁移。
EMBO J. 2017 Aug 15;36(16):2321-2333. doi: 10.15252/embj.201796436. Epub 2017 Jun 28.
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