• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

沙特阿拉伯东部地区志愿骨髓捐献者的 HLA-A、B、C、DRB1 和 DQB1 等位基因和单倍型频率。

HLA-A, B, C, DRB1 and DQB1 allele and haplotype frequencies in volunteer bone marrow donors from Eastern Region of Saudi Arabia.

机构信息

Cord Blood Bank, King Abdullah International Medical Research Center/College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences/King Abdulaziz Medical City-Riyadh, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Saudi Stem Cells Donor Registry, King Abdullah International Medical Research Center/King Saud Bin Abdulaziz University for Health Sciences/King Abdulaziz Medical City-Riyadh, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

出版信息

HLA. 2019 Jul;94(1):49-56. doi: 10.1111/tan.13533. Epub 2019 Apr 14.

DOI:10.1111/tan.13533
PMID:30903680
Abstract

We analyzed HLA allele and haplotype frequencies from donors from the Eastern region of Saudi Arabia. A cross-sectional study was performed on 2405 bone marrow donors from the Eastern region. HLA typing was carried out by sequencing. The most common HLA allele groups were HLA-A02:01:01G (11.08%), A01:01:01G (10.40%), HLA-B52:01:01G (8.79%), B18:01:01G (8.07%), HLA-C04:01:01G (17.88%), C12:03:01G (10.23%), HLA-DRB110:01 (14.89%), DRB103:01:01G (14.10%), HLA-DQB102:01:01G (24.53%) and DQB105:01:01G (20.17%). The most frequent HLA-A C B DRB1 DQB1 haplotypes were HLA-A01:03 C15:05:01G B73:01 DRB110:01:01 DQB105:01:01G (3.11%) and HLA-A01:01:01G C12:02:01G B52:01:01G DRB115:02:01 DQB106:01:01G (2.25%). When comparing the allele and haplotype frequencies of the Eastern regions' population to those from the Central region we found significant differences in several allele frequencies including A01:01:01G (P ≤ 0.0001), B52:01:01G (P ≤ 0.0001), B18:01:01G (P = 0.0001), C12:03:01G (P < 0.0001), DRB110:01:01 (P < 0.0001) and DQB105:01:01G (P < 0.0001). Our data confirms genetic heterogeneity among the Saudi population.

摘要

我们分析了来自沙特阿拉伯东部地区供体的 HLA 等位基因和单倍型频率。对来自东部地区的 2405 名骨髓供体进行了横断面研究。HLA 分型通过测序进行。最常见的 HLA 等位基因组是 HLA-A02:01:01G（11.08%）、A01:01:01G（10.40%）、HLA-B52:01:01G（8.79%）、B18:01:01G（8.07%）、HLA-C04:01:01G（17.88%）、C12:03:01G（10.23%）、HLA-DRB110:01（14.89%）、DRB103:01:01G（14.10%）、HLA-DQB102:01:01G（24.53%）和 DQB105:01:01G（20.17%）。最常见的 HLA-A、C、B、DRB1 和 DQB1 单倍型是 HLA-A01:03 C15:05:01G B73:01 DRB110:01:01 DQB105:01:01G（3.11%）和 HLA-A01:01:01G C12:02:01G B52:01:01G DRB115:02:01 DQB106:01:01G（2.25%）。当将东部地区人群的等位基因和单倍型频率与中部地区进行比较时，我们发现几个等位基因频率存在显著差异，包括 A01:01:01G（P≤0.0001）、B52:01:01G（P≤0.0001）、B18:01:01G（P=0.0001）、C12:03:01G（P<0.0001）、DRB110:01:01（P<0.0001）和 DQB105:01:01G（P<0.0001）。我们的数据证实了沙特人群中的遗传异质性。

相似文献

1
HLA-A, B, C, DRB1 and DQB1 allele and haplotype frequencies in volunteer bone marrow donors from Eastern Region of Saudi Arabia.沙特阿拉伯东部地区志愿骨髓捐献者的 HLA-A、B、C、DRB1 和 DQB1 等位基因和单倍型频率。
HLA. 2019 Jul;94(1):49-56. doi: 10.1111/tan.13533. Epub 2019 Apr 14.
2
HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 Allele and Haplotype Frequencies of 28,927 Saudi Stem Cell Donors Typed by Next-Generation Sequencing.28927 名沙特造血干细胞捐献者的 HLA-A、-B、-C、-DRB1、-DQB1 和-DPB1 等位基因和单体型频率，通过下一代测序进行分型。
Front Immunol. 2020 Oct 22;11:544768. doi: 10.3389/fimmu.2020.544768. eCollection 2020.
3
Human Leukocyte Antigen-A, B, C, DRB1, and DQB1 Allele and Haplotype Frequencies in a Subset of 237 Donors in the South African Bone Marrow Registry.在南非骨髓登记处的 237 名供者亚群中，人类白细胞抗原-A、B、C、DRB1 和 DQB1 等位基因和单倍型频率。
J Immunol Res. 2018 Apr 23;2018:2031571. doi: 10.1155/2018/2031571. eCollection 2018.
4
Distributions of the HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 alleles and haplotype frequencies of 1763 stem cell donors in the Colombian Bone Marrow Registry typed by next-generation sequencing.通过下一代测序对哥伦比亚骨髓登记处的 1763 名干细胞供者进行 HLA-A、HLA-B、HLA-C、HLA-DRB1 和 HLA-DQB1 等位基因和单倍型频率的分布。
Front Immunol. 2023 Jan 9;13:1057657. doi: 10.3389/fimmu.2022.1057657. eCollection 2022.
5
HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies in the Serbian population.塞尔维亚人群中 HLA-A、-B、-C、-DRB1 和 -DQB1 等位基因和单倍型频率。
Hum Immunol. 2014 Mar;75(3):218-26. doi: 10.1016/j.humimm.2013.12.009. Epub 2013 Dec 27.
6
The distributions of HLA-A, HLA-B, HLA-C, HLA-DRB1 and HLA-DQB1 allele and haplotype at high-resolution level in Zhejiang Han population of China.中国浙江汉族人群中高分辨率水平的HLA-A、HLA-B、HLA-C、HLA-DRB1和HLA-DQB1等位基因及单倍型分布
Int J Immunogenet. 2019 Feb;46(1):7-16. doi: 10.1111/iji.12411. Epub 2018 Dec 28.
7
HLA -A, -C, -B, -DRB1, -DQB1 and -DPB1 allele and haplotype frequencies in 4514 healthy Norwegians.4514名健康挪威人的HLA -A、-C、-B、-DRB1、-DQB1和-DPB1等位基因及单倍型频率
Hum Immunol. 2018 Jul;79(7):527-529. doi: 10.1016/j.humimm.2018.04.012. Epub 2018 Apr 21.
8
Allele and Haplotype Frequencies of Human Leukocyte Antigen-A, -B, -C, -DRB1, and -DQB1 From Sequence-Based DNA Typing Data in Koreans.基于序列的韩国人DNA分型数据得出的人类白细胞抗原-A、-B、-C、-DRB1和-DQB1的等位基因及单倍型频率
Ann Lab Med. 2015 Jul;35(4):429-35. doi: 10.3343/alm.2015.35.4.429. Epub 2015 May 21.
9
Allele and haplotype frequencies of human leukocyte antigen-A, -B, -C, -DRB1, -DRB3/4/5, -DQA1, -DQB1, -DPA1, and -DPB1 by next generation sequencing-based typing in Koreans in South Korea.韩国人群中基于下一代测序的 HLA-A、-B、-C、-DRB1、-DRB3/4/5、-DQA1、-DQB1、-DPA1 和 -DPB1 等位基因和单体型频率。
PLoS One. 2021 Jun 21;16(6):e0253619. doi: 10.1371/journal.pone.0253619. eCollection 2021.
10
Determination of HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies in heart failure patients.测定心力衰竭患者 HLA-A、-B、-C、-DRB1 和 -DQB1 等位基因和单倍型频率。
ESC Heart Fail. 2019 Apr;6(2):388-395. doi: 10.1002/ehf2.12406. Epub 2019 Jan 23.

引用本文的文献

1
Contribution of HLA class I (A, B, C) and HLA class II (DRB1, DQA1, DQB1) alleles and haplotypes in exploring ethnic origin of central Tunisians.探讨 HLA Ⅰ类（A、B、C）和 HLA Ⅱ类（DRB1、DQA1、DQB1）等位基因和单体型在探索突尼斯中部人群种族起源中的作用。
BMC Med Genomics. 2024 Feb 29;17(1):65. doi: 10.1186/s12920-024-01821-x.
2
Prevalence of exposure to pharmacogenetic drugs by the Saudis treated at the health care centers of the Ministry of National Guard.沙特国民卫队医疗中心治疗的沙特人接触药物遗传学药物的患病率。
Saudi Pharm J. 2022 Aug;30(8):1181-1192. doi: 10.1016/j.jsps.2022.06.013. Epub 2022 Jun 22.
3
HLA Diversity in Saudi Population: High Frequency of Homozygous HLA Alleles and Haplotypes.
沙特人群中的HLA多样性：纯合HLA等位基因和单倍型的高频率
Front Genet. 2022 Jun 9;13:898235. doi: 10.3389/fgene.2022.898235. eCollection 2022.
4
Characterizing the diversity of MHC conserved extended haplotypes using families from the United Arab Emirates.利用来自阿拉伯联合酋长国的家族来描述 MHC 保守扩展单倍型的多样性。
Sci Rep. 2022 May 3;12(1):7165. doi: 10.1038/s41598-022-11256-y.
5
HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 Allele and Haplotype Frequencies of 28,927 Saudi Stem Cell Donors Typed by Next-Generation Sequencing.28927 名沙特造血干细胞捐献者的 HLA-A、-B、-C、-DRB1、-DQB1 和-DPB1 等位基因和单体型频率，通过下一代测序进行分型。
Front Immunol. 2020 Oct 22;11:544768. doi: 10.3389/fimmu.2020.544768. eCollection 2020.