Greimers R, Rongy A M, Defresne M P, Boniver J, Hooghe R
Leuk Res. 1986;10(7):777-82. doi: 10.1016/0145-2126(86)90297-3.
The MP2 cell line was established from a murine leukemia virus-induced thymic lymphoma. Half of the cells were consistently L3T4 positive and less than 5% of the cells were Lyt-2 positive. Single cell cloning on the basis of the presence or absence of Lyt-2 allowed the isolation of four clones with stable phenotypes: (1) Lyt-2-, L3T4-; (2) Lyt-2+, L3T4+; (3) Lyt-2-, L3T4+; (4) Lyt2+, L3T4-. These data are discussed in relation to tumour cell heterogeneity and to normal T-cell differentiation pathways.
MP2细胞系源自鼠白血病病毒诱导的胸腺淋巴瘤。一半细胞始终呈L3T4阳性，不到5%的细胞呈Lyt-2阳性。基于Lyt-2的有无进行单细胞克隆，可分离出四种表型稳定的克隆：(1) Lyt-2-，L3T4-；(2) Lyt-2+，L3T4+；(3) Lyt-2-，L3T4+；(4) Lyt2+，L3T4-。结合肿瘤细胞异质性和正常T细胞分化途径对这些数据进行了讨论。
