Marrie Ruth Ann
Departments of Internal Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
Clin Invest Med. 2019 Mar 23;42(1):E5-E12. doi: 10.25011/cim.v42i1.32383.
Multiple sclerosis (MS) is an inflammatory and degenerative condition affecting the central nervous system. Like many neurologic diseases, it is chronic and incurable, and confers a substantial burden on affected individuals, their families and society. Although many individuals suffering from a serious chronic disease also suffer from comorbid conditions, the important consequences of their interaction often receive little attention. This was particularly true for MS two decades ago. Broadening our perspective by better understanding the effects of comorbidity on an individual with a particular chronic disease offers us an opportunity to improve understanding of prognosis, personalize disease management, develop new therapeutic approaches and illuminate the pathophysiology of disease.
Studies examining the incidence, prevalence and outcomes related to comorbidity in MS will be discussed, along with areas requiring further investigation.
Comorbidity is highly prevalent in MS throughout the disease course. Comorbid conditions, including depression, anxiety, hypertension, hyperlipidemia, diabetes and chronic lung disease, adversely affect a broad range of outcomes. Less is known about the effects of MS on outcomes related to these comorbid conditions. These findings highlight an urgent need to determine how to best prevent and treat comorbidity in MS.
多发性硬化症（MS）是一种影响中枢神经系统的炎症性和退行性疾病。与许多神经系统疾病一样，它是慢性且无法治愈的，给患者本人、其家庭和社会带来了沉重负担。尽管许多患有严重慢性疾病的人也患有合并症，但其相互作用的重要后果往往很少受到关注。二十年前的MS尤其如此。通过更好地理解合并症对特定慢性疾病患者的影响来拓宽我们的视野，为我们提供了一个机会，以增进对预后的理解、使疾病管理个性化、开发新的治疗方法并阐明疾病的病理生理学。
将讨论研究MS合并症的发病率、患病率和相关结局的研究，以及需要进一步研究的领域。
合并症在MS整个病程中非常普遍。包括抑郁症、焦虑症、高血压、高脂血症、糖尿病和慢性肺病在内的合并症会对广泛的结局产生不利影响。关于MS对这些合并症相关结局的影响了解较少。这些发现凸显了迫切需要确定如何最好地预防和治疗MS中的合并症。
