Modesto A, Chira C, Sol J-C, Lubrano V, Boulinguez S, Pagès C, Sibaud V, Gomez-Roca C, Moyal É, Meyer N
Département de radiothérapie, institut Claudius-Regaud, institut universitaire du cancer de Toulouse-Oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.
Département de radiothérapie, institut Claudius-Regaud, institut universitaire du cancer de Toulouse-Oncopole, 1, avenue Irène-Joliot-Curie, 31059 Toulouse cedex 9, France.
Cancer Radiother. 2019 Apr;23(2):147-150. doi: 10.1016/j.canrad.2018.05.006. Epub 2019 Mar 21.
Whereas immune checkpoint inhibitors of serine/threonine protein kinase B-raf therapy dramatically changed metastatic outcomes of patients with melanoma, they remain at high risk of brain extension. Additional local treatment can be offered in this situation such as surgery and or stereotactic radiotherapy. In this review article, we describe the different options with published data and their optimal timing.
虽然丝氨酸/苏氨酸蛋白激酶B-raf治疗的免疫检查点抑制剂极大地改变了黑色素瘤患者的转移结局，但他们仍有很高的脑转移风险。在这种情况下，可以提供额外的局部治疗，如手术和/或立体定向放射治疗。在这篇综述文章中，我们描述了已发表数据的不同选择及其最佳时机。
