Vintzileos A M, Campbell W A, Storlazzi E, Mirochnick M H, Escoto D T, Nochimson D J
Obstet Gynecol. 1986 Aug;68(2):162-7.
Sixteen isoimmunized pregnancies at risk for erythroblastosis fetalis were managed by serial amniocenteses for bilirubin delta optical density at 450 nm (delta OD450). Before amniocentesis each fetus was evaluated ultrasonically and the fetal liver size, the abdominal circumference, and the umbilical vein diameter, in both the fetal liver and the umbilical cord, were measured. The ultrasonically determined fetal liver size, as well as its growth rate, was found to be greater than normal during the last two weeks before intervention (intrauterine transfusion or delivery) in all eight fetuses with severe hemolytic disease. The umbilical vein diameter in the fetal liver was above normal in only one fetus, whereas the abdominal circumference was increased in only three of the eight severely affected fetuses. These data suggest that serial fetal liver ultrasound measurements may be useful as an adjunct to amniotic fluid analysis to predict the severely affected fetus in need of prompt intervention (intrauterine transfusion or delivery).
对16例有胎儿成红细胞增多症风险的同种免疫妊娠患者，通过连续羊膜腔穿刺术测定450nm处胆红素的光密度差（ΔOD450）进行处理。在羊膜腔穿刺术前，对每个胎儿进行超声评估，并测量胎儿肝脏大小、腹围以及胎儿肝脏和脐带中的脐静脉直径。在干预（宫内输血或分娩）前的最后两周，发现所有8例患有严重溶血病的胎儿经超声测定的胎儿肝脏大小及其生长速率均大于正常。胎儿肝脏中的脐静脉直径仅在1例胎儿中高于正常，而在8例严重受影响的胎儿中，只有3例腹围增加。这些数据表明，连续进行胎儿肝脏超声测量作为羊水分析的辅助手段，可能有助于预测需要及时干预（宫内输血或分娩）的严重受影响胎儿。
