纳曲酮相关的视幻觉：一例报告
Naltrexone-associated Visual Hallucinations: A Case Report.
作者信息
Lee Dae Bo, Woo Young Sup, Bahk Won-Myong
机构信息
Department of Psychiatry, National Forensic Hospital.
Department of Psychiatry, College of Medicine, The Catholic University of Korea.
出版信息
Clin Psychopharmacol Neurosci. 2019 May 31;17(2):329-331. doi: 10.9758/cpn.2019.17.2.329.
Abstract
Naltrexone is a competitive antagonist of Μ, δ, and κ opioid receptors. Naltrexone has been investigated for use an as anti-obesity agent in both the general population and in patients with severe mental illness, including schizophrenia. In patients with schizophrenia, however, potential psychotic symptoms due to adverse effects of naltrexone have not been investigated. Our case study, a relevant case report, and some related articles suggest that naltrexone might be associated with the emergence of visual hallucinations, which clinicians should be aware of.
摘要
纳曲酮是μ、δ和κ阿片受体的竞争性拮抗剂。纳曲酮已被研究用于普通人群和包括精神分裂症在内的严重精神疾病患者的抗肥胖药物。然而，在精神分裂症患者中，尚未对纳曲酮不良反应导致的潜在精神症状进行研究。我们的病例研究、一份相关病例报告以及一些相关文章表明，纳曲酮可能与视幻觉的出现有关，临床医生应予以关注。
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Naltrexone-associated Visual Hallucinations: A Case Report.纳曲酮相关的视幻觉：一例报告
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本文引用的文献
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The efficacy and safety of the naltrexone/bupropion combination for the treatment of obesity: an update.纳曲酮/安非他酮联合用药治疗肥胖症的疗效与安全性：最新进展
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Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons.κ阿片类激动剂和μ阿片类激动剂均抑制腹侧被盖区神经元的谷氨酸能输入。
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