Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Lovisenberg Diaconal Hospital, Oslo, Norway.
Neuropsychol Rehabil. 2020 Sep;30(8):1449-1476. doi: 10.1080/09602011.2019.1589530. Epub 2019 Mar 24.
Post-stroke fatigue (PSF) is a common and often disabling consequence of stroke, considered to be a complex multidimensional phenomenon. The present review sought to identify studies examining associations between PSF and at least one factor, with the objective of identifying factors that should be investigated in patients with PSF.
A search for research investigating PSF was conducted through PubMed, CINAHL and Psychinfo databases (19 October 2017), and included studies in English published during the last 15 years, with more than 10 stroke participants (>18 years old), fatigue assessed with quantitative measurements, and reported relationship with one or more associated factor/-s.
Overall, 281 papers were identified of which 34 were included in the final review. Demographics (gender, age), emotional health (depression, anxiety, coping strategy, and locus of control), clinical factors (sleep, pain, stroke characteristics, biological and immunological factors), social factors (social support, disabilities and functionality in daily life) and cognitive functions were found to be associated with PSF. A new framework is discussed, incorporating modifiability of PSF-related factors to heighten the clinical utility.
Post-stroke fatigue is multidimensional phenomena with complex aetiology. Further studies are needed to investigate whether treating associated modifiable factors also can decrease PSF.
中风后疲劳（PSF）是中风的一种常见且常致残的后果，被认为是一种复杂的多维现象。本综述旨在确定研究 PSF 与至少一个因素之间关系的研究，目的是确定应在 PSF 患者中进行调查的因素。
通过 PubMed、CINAHL 和 Psychinfo 数据库（2017 年 10 月 19 日）搜索研究 PSF 的研究，纳入了过去 15 年发表的英语研究，研究对象为超过 10 名中风参与者（>18 岁），使用定量测量评估疲劳，并报告与一个或多个相关因素的关系。
共确定了 281 篇论文，其中 34 篇纳入最终综述。人口统计学特征（性别、年龄）、情绪健康（抑郁、焦虑、应对策略、控制源）、临床因素（睡眠、疼痛、中风特征、生物和免疫因素）、社会因素（社会支持、残疾和日常生活功能）和认知功能与 PSF 相关。讨论了一个新的框架，纳入了 PSF 相关因素的可修饰性，以提高临床实用性。
中风后疲劳是一种具有复杂病因的多维现象。需要进一步研究来调查治疗相关可修饰因素是否也可以减轻 PSF。
