在乳腺癌发病机制中，药理学 TGF-β 信号通路抑制剂的治疗潜力。
Therapeutic potential of pharmacological TGF-β signaling pathway inhibitors in the pathogenesis of breast cancer.
机构信息
Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Biochem Pharmacol. 2019 Jun;164:17-22. doi: 10.1016/j.bcp.2019.03.031. Epub 2019 Mar 21.
The TGF-β signaling pathway plays an important role in cancer cell proliferation, growth, inflammation, angiogenesis, and metastasis. The role of TGF-β signaling in the pathogenesis of breast cancer is complex. TGF-β acts as a tumor suppressor in the early stages of disease, and as a tumor promoter in its later stages. Over-activation of the TGF-β signaling pathway and over-expression of the TGF-β receptors are frequently found in breast tumors. Suppression of TGF-β pathway using biological or pharmacological inhibitors is a potentially novel therapeutic approach for breast cancer treatment. This review summarizes the regulatory role of TGF-β signaling in the pathogenesis of breast cancer for a better understanding and hence a better management of this disease.
TGF-β 信号通路在癌细胞增殖、生长、炎症、血管生成和转移中发挥着重要作用。TGF-β 信号在乳腺癌发病机制中的作用较为复杂。在疾病早期，TGF-β 作为肿瘤抑制因子起作用，而在疾病后期，TGF-β 则作为肿瘤促进因子起作用。在乳腺癌肿瘤中，TGF-β 信号通路过度激活，TGF-β 受体过度表达的情况较为常见。使用生物或药理学抑制剂抑制 TGF-β 通路是治疗乳腺癌的一种潜在新型治疗方法。本综述总结了 TGF-β 信号在乳腺癌发病机制中的调控作用，以更好地理解和管理这种疾病。
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